TY - JOUR
T1 - Microalbuminuria - Potential marker for increased cardiovascular risk factors in nondiabetic subjects?
AU - Haffner, Steven M.
AU - Stern, Michael P.
AU - Katherine Kozlowski Gruber, M.
AU - Hazuda, Helen P.
AU - Mitchell, Braxton D.
AU - Patterson, Judith K.
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1990
Y1 - 1990
N2 - Microalbuminuria is associated with progression to renal disease in insulin-dependent diabetes and with increased mortality in noninsulin-dependent diabetes. In contrast, few studies have addressed the effect of microalbuminuria on cardiovascular risk in nondiabetics. We, therefore, determined the level of microalbuminuria in 316 nondiabetic subjects from the San Antonio Heart Study, a population-based study of diabetes and cardiovascular risk factors. Microalbuminuria (≥30 mg/l) was found in 42 of these 316 subjects (13%). Subjects with microalbuminuria had significantly higher blood pressure, triglyceride concentration, sum of insulin concentrations during a glucose tolerance test, and prevalence of hypertension and of self-reported myocardial infarction than subjects without microalbuminuria. When subjects with hypertension were excluded (n=27), normotensive subjects with microalbuminuria (n=31) still had significantly higher triglyceride concentrations and insulin sum than normotensive subjects without microalbuminuria (n=258), suggesting that an increased atherogenic risk factor pattern exists even in normotensive subjects with microalbuminuria. Microalbuminuria may be a marker for cardiovascular risk, although it is not certain whether microalbuminuria causes these metabolic changes or results from some metabolic disturbance such as insulin resistance.
AB - Microalbuminuria is associated with progression to renal disease in insulin-dependent diabetes and with increased mortality in noninsulin-dependent diabetes. In contrast, few studies have addressed the effect of microalbuminuria on cardiovascular risk in nondiabetics. We, therefore, determined the level of microalbuminuria in 316 nondiabetic subjects from the San Antonio Heart Study, a population-based study of diabetes and cardiovascular risk factors. Microalbuminuria (≥30 mg/l) was found in 42 of these 316 subjects (13%). Subjects with microalbuminuria had significantly higher blood pressure, triglyceride concentration, sum of insulin concentrations during a glucose tolerance test, and prevalence of hypertension and of self-reported myocardial infarction than subjects without microalbuminuria. When subjects with hypertension were excluded (n=27), normotensive subjects with microalbuminuria (n=31) still had significantly higher triglyceride concentrations and insulin sum than normotensive subjects without microalbuminuria (n=258), suggesting that an increased atherogenic risk factor pattern exists even in normotensive subjects with microalbuminuria. Microalbuminuria may be a marker for cardiovascular risk, although it is not certain whether microalbuminuria causes these metabolic changes or results from some metabolic disturbance such as insulin resistance.
KW - Blood pressure
KW - Diabetes
KW - Insulin resistance
KW - Lipids
KW - Lipoproteins
KW - Microalbuminuria
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U2 - 10.1161/01.ATV.10.5.727
DO - 10.1161/01.ATV.10.5.727
M3 - Article
C2 - 2403300
AN - SCOPUS:0025026160
VL - 10
SP - 727
EP - 731
JO - Arteriosclerosis, Thrombosis, and Vascular Biology
JF - Arteriosclerosis, Thrombosis, and Vascular Biology
SN - 1079-5642
IS - 5
ER -