Miconazole: A historical perspective

Annette W. Fothergill

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

Miconazole is an imidazole that has been successfully used for over 30 years for the treatment of superficial and cutaneous disease. This agent is distinguished from other azoles by possessing two mechanisms of action. The first mechanism is shared with other azoles and involves the inhibition of ergosterol synthesis. Another mechanism involves inhibition of peroxidases, which results in the accumulation of peroxide within the cell resulting in cell death. Susceptibility patterns for miconazole demonstrate that yeast fungi remain largely susceptible even in light of repeated exposures. Despite the release of newer azoles and other classes of antifungals, miconazole remains a highly prescribed treatment for vaginal candidiasis.

Original languageEnglish (US)
Pages (from-to)171-175
Number of pages5
JournalExpert Review of Anti-Infective Therapy
Volume4
Issue number2
DOIs
StatePublished - Apr 2006

Keywords

  • Antifungal susceptibility
  • Azole
  • Candidiasis
  • Miconazole
  • Resistance

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Virology
  • Infectious Diseases

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