MIC values of voriconazole are predictive of treatment results in murine infections by aspergillus terreus species complex

Valentina Salas, F. Javier Pastor, Deanna A. Sutton, Enrique Calvo, Emilio Mayayo, Annette W. Fothergill, Michael G. Rinaldi, Josep Guarro

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

We evaluated the efficacy of voriconazole against nine strains of Aspergillus terreus with different MICs (0.12 to 4 μg/ml) by using a murine model. Markers of efficacy included survival, tissue burden, galactomannan antigenemia, and drug serum levels. Voriconazole was especially effective in prolonging survival and reducing the fungal load in infections by strains that showed MICs that were less than or equal to the epidemiological cutoff value (1 μg/ml). In vitro data might be useful for predicting the outcome of A. terreus infections.

Original languageEnglish (US)
Pages (from-to)1532-1534
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume57
Issue number3
DOIs
StatePublished - Mar 1 2013

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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