Methylenetetrahydrofolate reductase polymorphisms are not a risk factor for pre-eclampsia/eclampsia in Australian women

Thomas Kaiser, Shaun P. Brennecke, Eric K. Moses

    Research output: Contribution to journalArticlepeer-review

    38 Scopus citations

    Abstract

    In European and Japanese but not in Australian, American, and South African women, the C677T methylenetetrahydrofolate reductase (MTHFR) polymorphism has been reported to be a genetic risk factor pre- eclampsia/eclampsia (PE/E). The recently described A1298C MTHFR gene polymorphism also results in reduced MTHFR enzyme activity, although to a lesser extent than the previously described C677T polymorphism. Heterozygotes for both polymorphisms are reported to have an even lower MTHFR enzymatic activity than seen in homozygotes for the C677T genotype. In this current study we determined the allele frequency of the A1298C MTHFR gene polymorphism in an Australian population and examined this polymorphism alone and in combination with the C677T MTHFR polymorphism for an association with PE/E. Neither the A1298C polymorphism alone nor a combination of both polymorphisms showed an association with PE/E in our population of Australian women. Copyright (C) 2000 S. Karger AG, Basel.

    Original languageEnglish (US)
    Pages (from-to)100-102
    Number of pages3
    JournalGynecologic and Obstetric Investigation
    Volume50
    Issue number2
    DOIs
    StatePublished - Jan 1 2000

    Keywords

    • A1298C
    • C677T
    • Eclampsia
    • Homocysteine
    • Methylenetetrahydrofolate reductase
    • Polymorphisms
    • Pre-eclampsia

    ASJC Scopus subject areas

    • Reproductive Medicine
    • Obstetrics and Gynecology

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