Methylene blue treatment delays progression of perfusion-diffusion mismatch to infarct in permanent ischemic stroke

Pavel Rodriguez, Zhao Jiang, Shiliang Huang, Qiang Shen, Timothy Q. Duong

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Stroke is a leading cause of morbidity and mortality in the world. Low-dose methylene blue (MB), which has been used safely to treat methemoglobinemia and cyanide poisoning in humans, has energy enhancing and antioxidant properties. We tested the hypothesis that methylene blue treatment delays progression of at-risk tissue (ca. perfusion-diffusion mismatch) to infarct in permanent middle cerebral artery occlusion in rats at two MB treatment doses. Serial MRI was used to evaluate MB treatment efficacy. The major findings were: (i) MB significantly prolonged the perfusion-diffusion mismatch, (ii) MB mildly increased the CBF in the hypoperfused tissue, (iii) MB did not change the final infarct volume in permanent ischemic stroke, and (iv) there were no dose-dependent effects on mismatch progression for the 1 and 3 mg/kg doses studied. This neuroprotective effect is likely the result of sustained ATP production and increased CBF to tissue at risk. This work has the potential to readily lead to clinical stroke trials given MB's excellent safety profile.

Original languageEnglish (US)
Pages (from-to)144-149
Number of pages6
JournalBrain Research
Volume1588
DOIs
StatePublished - Nov 7 2014

Keywords

  • Infarct volume
  • Ischemic penumbra Neuroprotection
  • MRI
  • Middle-cerebral artery occlusion
  • Oxidative stress

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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