Methusaleh's Zoo: How Nature provides us with Clues for Extending Human Health Span

S. N. Austad

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

As impressive as the accomplishments of modern molecular biologists have been in finding genetic alterations that lengthen life in short-lived model organisms, they pale in comparison to the remarkable diversity of lifespans produced by evolution. Some animal species are now firmly documented to live for more than four centuries and even some mammals, like the bowhead whale, appear to survive 200 years or more. Another group of species may not be as absolutely long-lived, but they are remarkably long-lived for their body size and metabolic rate. These species include a number of bats, some of which live for at least 40 years in the wild, as well as the naked mole-rat, which is the same size, but lives nearly 10 times as long as the laboratory mouse. Together these exceptionally long-lived organisms have important roles to play in our future understanding of the causal mechanisms and modulation of ageing. Bats and naked mole-rats in particular have already contributed in the following ways: (1) they have contributed to the abandonment of the rate-of-living theory and weakened enthusiasm for the oxidative stress hypothesis of ageing, (2) they have helped evaluate how the tumour-suppressing role of cellular senescence is affected by the evolution of diverse body sizes as well as diverse longevities, (3) they have shed light on the relationship between specific types of DNA repair and ageing and (4) they have yielded insight into new processes, specifically the maintenance of the proteome and hypotheses concerning how evolution shapes ageing. The continuing acceleration of progress in genome sequencing and development of more and more cross-species investigatory techniques will facilitate even more contributions of these species in the near future.

Original languageEnglish (US)
JournalJournal of Comparative Pathology
Volume142
Issue numberSUPPL. 1
DOIs
StatePublished - Jan 2010

Fingerprint

Mole Rats
Body Size
zoos
Heterocephalus glaber
Bowhead Whale
human health
Chiroptera
Cell Aging
Health
Proteome
body size
DNA Repair
Mammals
Oxidative Stress
organisms
Maintenance
Genome
DNA repair
proteome
biologists

Keywords

  • ageing
  • animal model
  • life span

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • veterinary(all)

Cite this

Methusaleh's Zoo : How Nature provides us with Clues for Extending Human Health Span. / Austad, S. N.

In: Journal of Comparative Pathology, Vol. 142, No. SUPPL. 1, 01.2010.

Research output: Contribution to journalArticle

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