Methenamine for Recurrent Urinary Tract Infections in Solid Organ Transplantation

Helen Sweiss, Suverta Bhayana, Reed Hall, Joelle Nelson, Elisabeth Kincaide

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


Introduction: Recurrent urinary tract infections remain a challenge in solid organ transplant and have a negative impact on morbidity/mortality. Project Aim: The purpose of this program evaluation was to determine the impact of methenamine on recurrent urinary tract infection in kidney and liver-kidney transplant recipients. Design: This retrospective review included patients > 18 years of age who received a kidney or liver-kidney transplant. Patients were divided into the following groups: (1) Methenamine therapy initiation received methenamine for ≥ 180 days or (2) Non-methenamine therapy: did not receive recurrent urinary tract infection prophylaxis. A total of 60 patients were included. Results: When comparing outcomes between methenamine therapy initiation and non-methenamine therapy group, a significant reduction in the rate of recurrent urinary tract infection was reported in the methenamine therapy initiation group (0.6 vs 1.3 per 180 patient days follow-up, P = 0.0005). A significant reduction was also noted with rate of asymptomatic bacteriuria, treatment failures, bacteremia, hospitalizations due to recurrent urinary tract infection, multi-drug resistant organism isolated, and the average duration of antibiotic use. A significant difference in the time to failure of methenamine therapy initiation versus non-methenamine therapy is noted up to 180 patient-days follow-up (RR 1.56, P = 0.0019). Conclusion: This evaluation supported methenamine therapy for recurrent urinary tract infection in kidney and liver-kidney transplant. The most significant impact of methenamine recurrent urinary tract infection was seen in the first 30 days after initiation.

Original languageEnglish (US)
Pages (from-to)67-72
Number of pages6
JournalProgress in Transplantation
Issue number1
StatePublished - Mar 2022


  • clinical outcomes
  • descriptive comparative
  • diabetes
  • education
  • general urinary tract infection, prophylaxis, methenamine
  • health
  • infection
  • performance improvement
  • quality
  • quantitative methods
  • research
  • systems

ASJC Scopus subject areas

  • Transplantation


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