Metastasis to bone: Causes, consequences and therapeutic opportunities

Gregory R. Mundy

Research output: Contribution to journalReview articlepeer-review

2261 Scopus citations

Abstract

The most common human cancers - lung, breast and prostate - have a great avidity for bone, leading to painful and untreatable consequences. What makes some cancers, but not others, metastasize to bone, and how do they alter its physiology? Some of the molecular mechanisms that are responsible have recently been identified, and provide new molecular targets for drug development.

Original languageEnglish (US)
Pages (from-to)584-593
Number of pages10
JournalNature Reviews Cancer
Volume2
Issue number8
DOIs
StatePublished - Aug 2002

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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