Metastasis from squamous cell carcinomas of SENCAR mouse skin produced by complete carcinogenesis

George J. Patskan; Andres J.P. Klein-Szanto; James L. Phillips; Thomas J. Slaga

doi:10.1016/0304-3835(87)90002-4

Metastasis from squamous cell carcinomas of SENCAR mouse skin produced by complete carcinogenesis

George J. Patskan, Andres J.P. Klein-Szanto, James L. Phillips, Thomas J. Slaga

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

The incidence of metastasis was evaluated in female SENCAR mice after induction of squamous cell carcinomas by repetitive applications of either benzo[a]pyrene (B[a]P) or N-methyl-N′-nitro-N-nitrosogaunidine (MNNG). Between 41 and 50 weeks 50% of the animals with carcinomas in the B[a]P group had metastases, whereas 20% had metastases in the MNNG group. Very few metastases were observed before 40 weeks of treatment. The major site of metastasis was the lungs; however, metastatic tumors were also found in lymph nodes, adrenal glands and kidneys.

Original language	English (US)
Pages (from-to)	121-127
Number of pages	7
Journal	Cancer Letters
Volume	34
Issue number	2
DOIs	https://doi.org/10.1016/0304-3835(87)90002-4
State	Published - Feb 1987
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

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@article{14c7bdb90ff94499950a4d0975aa1ad5,

title = "Metastasis from squamous cell carcinomas of SENCAR mouse skin produced by complete carcinogenesis",

abstract = "The incidence of metastasis was evaluated in female SENCAR mice after induction of squamous cell carcinomas by repetitive applications of either benzo[a]pyrene (B[a]P) or N-methyl-N′-nitro-N-nitrosogaunidine (MNNG). Between 41 and 50 weeks 50% of the animals with carcinomas in the B[a]P group had metastases, whereas 20% had metastases in the MNNG group. Very few metastases were observed before 40 weeks of treatment. The major site of metastasis was the lungs; however, metastatic tumors were also found in lymph nodes, adrenal glands and kidneys.",

author = "Patskan, {George J.} and Klein-Szanto, {Andres J.P.} and Phillips, {James L.} and Slaga, {Thomas J.}",

note = "Funding Information: This work was supported by NIH grants CA-34890, CA-34962C, A-34521 and CA-09480. We thank Joann Fries for her excellent technical assistance, and Joyce Mayhugh and Carol Hildman for their help in preparing this manuscript.",

year = "1987",

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doi = "10.1016/0304-3835(87)90002-4",

language = "English (US)",

volume = "34",

pages = "121--127",

journal = "Cancer Letters",

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T1 - Metastasis from squamous cell carcinomas of SENCAR mouse skin produced by complete carcinogenesis

AU - Patskan, George J.

AU - Klein-Szanto, Andres J.P.

AU - Phillips, James L.

AU - Slaga, Thomas J.

N1 - Funding Information: This work was supported by NIH grants CA-34890, CA-34962C, A-34521 and CA-09480. We thank Joann Fries for her excellent technical assistance, and Joyce Mayhugh and Carol Hildman for their help in preparing this manuscript.

PY - 1987/2

Y1 - 1987/2

N2 - The incidence of metastasis was evaluated in female SENCAR mice after induction of squamous cell carcinomas by repetitive applications of either benzo[a]pyrene (B[a]P) or N-methyl-N′-nitro-N-nitrosogaunidine (MNNG). Between 41 and 50 weeks 50% of the animals with carcinomas in the B[a]P group had metastases, whereas 20% had metastases in the MNNG group. Very few metastases were observed before 40 weeks of treatment. The major site of metastasis was the lungs; however, metastatic tumors were also found in lymph nodes, adrenal glands and kidneys.

AB - The incidence of metastasis was evaluated in female SENCAR mice after induction of squamous cell carcinomas by repetitive applications of either benzo[a]pyrene (B[a]P) or N-methyl-N′-nitro-N-nitrosogaunidine (MNNG). Between 41 and 50 weeks 50% of the animals with carcinomas in the B[a]P group had metastases, whereas 20% had metastases in the MNNG group. Very few metastases were observed before 40 weeks of treatment. The major site of metastasis was the lungs; however, metastatic tumors were also found in lymph nodes, adrenal glands and kidneys.

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