Metastasis from squamous cell carcinomas of SENCAR mouse skin produced by complete carcinogenesis

George J. Patskan, Andres J.P. Klein-Szanto, James L. Phillips, Thomas J. Slaga

Research output: Contribution to journalArticle

13 Scopus citations


The incidence of metastasis was evaluated in female SENCAR mice after induction of squamous cell carcinomas by repetitive applications of either benzo[a]pyrene (B[a]P) or N-methyl-N′-nitro-N-nitrosogaunidine (MNNG). Between 41 and 50 weeks 50% of the animals with carcinomas in the B[a]P group had metastases, whereas 20% had metastases in the MNNG group. Very few metastases were observed before 40 weeks of treatment. The major site of metastasis was the lungs; however, metastatic tumors were also found in lymph nodes, adrenal glands and kidneys.

Original languageEnglish (US)
Pages (from-to)121-127
Number of pages7
JournalCancer Letters
Issue number2
StatePublished - Feb 1987
Externally publishedYes


ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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