Abstract
The incidence of metastasis was evaluated in female SENCAR mice after induction of squamous cell carcinomas by repetitive applications of either benzo[a]pyrene (B[a]P) or N-methyl-N′-nitro-N-nitrosogaunidine (MNNG). Between 41 and 50 weeks 50% of the animals with carcinomas in the B[a]P group had metastases, whereas 20% had metastases in the MNNG group. Very few metastases were observed before 40 weeks of treatment. The major site of metastasis was the lungs; however, metastatic tumors were also found in lymph nodes, adrenal glands and kidneys.
Original language | English (US) |
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Pages (from-to) | 121-127 |
Number of pages | 7 |
Journal | Cancer Letters |
Volume | 34 |
Issue number | 2 |
DOIs | |
State | Published - Feb 1987 |
Externally published | Yes |
ASJC Scopus subject areas
- Oncology
- Cancer Research