Metastasis from squamous cell carcinomas of SENCAR mouse skin produced by complete carcinogenesis

George J. Patskan, Andres J P Klein-Szanto, James L. Phillips, Thomas J Slaga

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The incidence of metastasis was evaluated in female SENCAR mice after induction of squamous cell carcinomas by repetitive applications of either benzo[a]pyrene (B[a]P) or N-methyl-N′-nitro-N-nitrosogaunidine (MNNG). Between 41 and 50 weeks 50% of the animals with carcinomas in the B[a]P group had metastases, whereas 20% had metastases in the MNNG group. Very few metastases were observed before 40 weeks of treatment. The major site of metastasis was the lungs; however, metastatic tumors were also found in lymph nodes, adrenal glands and kidneys.

Original languageEnglish (US)
Pages (from-to)121-127
Number of pages7
JournalCancer Letters
Volume34
Issue number2
DOIs
StatePublished - 1987
Externally publishedYes

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Inbred SENCAR Mouse
Squamous Cell Carcinoma
Carcinogenesis
Neoplasm Metastasis
Skin
Benzo(a)pyrene
Adrenal Glands
Lymph Nodes
Carcinoma
Kidney
Lung
Incidence
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

Cite this

Metastasis from squamous cell carcinomas of SENCAR mouse skin produced by complete carcinogenesis. / Patskan, George J.; Klein-Szanto, Andres J P; Phillips, James L.; Slaga, Thomas J.

In: Cancer Letters, Vol. 34, No. 2, 1987, p. 121-127.

Research output: Contribution to journalArticle

Patskan, George J. ; Klein-Szanto, Andres J P ; Phillips, James L. ; Slaga, Thomas J. / Metastasis from squamous cell carcinomas of SENCAR mouse skin produced by complete carcinogenesis. In: Cancer Letters. 1987 ; Vol. 34, No. 2. pp. 121-127.
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