Abstract
The incidence of metastasis was evaluated in female SENCAR mice after induction of squamous cell carcinomas by repetitive applications of either benzo[a]pyrene (B[a]P) or N-methyl-N′-nitro-N-nitrosogaunidine (MNNG). Between 41 and 50 weeks 50% of the animals with carcinomas in the B[a]P group had metastases, whereas 20% had metastases in the MNNG group. Very few metastases were observed before 40 weeks of treatment. The major site of metastasis was the lungs; however, metastatic tumors were also found in lymph nodes, adrenal glands and kidneys.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 121-127 |
| Number of pages | 7 |
| Journal | Cancer Letters |
| Volume | 34 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1987 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Cancer Research
- Molecular Biology
- Oncology
Cite this
Metastasis from squamous cell carcinomas of SENCAR mouse skin produced by complete carcinogenesis. / Patskan, George J.; Klein-Szanto, Andres J P; Phillips, James L.; Slaga, Thomas J.
In: Cancer Letters, Vol. 34, No. 2, 1987, p. 121-127.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Metastasis from squamous cell carcinomas of SENCAR mouse skin produced by complete carcinogenesis
AU - Patskan, George J.
AU - Klein-Szanto, Andres J P
AU - Phillips, James L.
AU - Slaga, Thomas J
PY - 1987
Y1 - 1987
N2 - The incidence of metastasis was evaluated in female SENCAR mice after induction of squamous cell carcinomas by repetitive applications of either benzo[a]pyrene (B[a]P) or N-methyl-N′-nitro-N-nitrosogaunidine (MNNG). Between 41 and 50 weeks 50% of the animals with carcinomas in the B[a]P group had metastases, whereas 20% had metastases in the MNNG group. Very few metastases were observed before 40 weeks of treatment. The major site of metastasis was the lungs; however, metastatic tumors were also found in lymph nodes, adrenal glands and kidneys.
AB - The incidence of metastasis was evaluated in female SENCAR mice after induction of squamous cell carcinomas by repetitive applications of either benzo[a]pyrene (B[a]P) or N-methyl-N′-nitro-N-nitrosogaunidine (MNNG). Between 41 and 50 weeks 50% of the animals with carcinomas in the B[a]P group had metastases, whereas 20% had metastases in the MNNG group. Very few metastases were observed before 40 weeks of treatment. The major site of metastasis was the lungs; however, metastatic tumors were also found in lymph nodes, adrenal glands and kidneys.
UR - http://www.scopus.com/inward/record.url?scp=0023134680&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023134680&partnerID=8YFLogxK
U2 - 10.1016/0304-3835(87)90002-4
DO - 10.1016/0304-3835(87)90002-4
M3 - Article
C2 - 3815325
AN - SCOPUS:0023134680
VL - 34
SP - 121
EP - 127
JO - Cancer Letters
JF - Cancer Letters
SN - 0304-3835
IS - 2
ER -