Metarrhizium anisopliae as a cause of sinusitis in immunocompetent hosts

Sanjay G. Revankar, Deanna A. Sutton, Stephen E. Sanche, Jyothi Rao, Marcus Zervos, Farnaz Dashti, Michael G. Rinaldi

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


Metarrhizium anisopliae is a common pathogen of insects and has even been used to control insect populations. It is rarely isolated from human or animal sources, but recently, there have been three reported cases of disease, two in humans and one in a cat. We present our experience with five isolates from human sources, including two that were the apparent causes of two cases of sinusitis in immunocompetent hosts. The first patient was a 36- year-old male with frontal and ethmoid sinusitis, and the second was a 79- year-old female with chronic sinusitis. Both patients underwent surgery, and pathology of the surgical specimens revealed branching hyphae. Cultures grew only Metarrhizium species. Neither patient received antifungal therapy, and both did well postoperatively. The other three isolates were cultured from bronchoalveolar lavage specimens but were not felt to be clinically significant. Antifungal susceptibility testing using the National Committee for Clinical Laboratory Standards macrobroth method revealed that all isolates were resistant to amphotericin B, 5-flucytosine, and fluconazole. Itraconazole and newer azole compounds were more active. Metarrhizium species may cause disease in humans, even those without evidence of immunosuppression, and are apparently highly resistant to amphotericin B in vitro.

Original languageEnglish (US)
Pages (from-to)195-198
Number of pages4
JournalJournal of clinical microbiology
Issue number1
StatePublished - Jan 1999

ASJC Scopus subject areas

  • Microbiology (medical)


Dive into the research topics of 'Metarrhizium anisopliae as a cause of sinusitis in immunocompetent hosts'. Together they form a unique fingerprint.

Cite this