Metallic stent mesh coated with silver nanoparticles suppresses stent-induced tissue hyperplasia and biliary sludge in the rabbit extrahepatic bile duct

Wooram Park, Kun Yung Kim, Jeon Min Kang, Dae Sung Ryu, Dong Hyun Kim, Ho Young Song, Seong Hun Kim, Seung Ok Lee, Jung Hoon Park

Research output: Contribution to journalArticle

Abstract

Recent therapeutic strategies to suppress restenosis after biliary stent placement are insufficient. Here, we demonstrate the usefulness of a self-expandable metal stent (SEMS), a stent mesh coated with silver nanoparticles (AgNPs), for suppression of both stent-induced tissue hyperplasia and biliary sludge formation in the rabbit bile duct. The AgNP-coated SEMSs were prepared using a simple bio-inspired surface modification process. Then, the prepared SEMSs were successfully placed in 22 of 24 rabbits. Sludge formation in the AgNP-coated SEMS groups was significantly decreased compared to the control group on gross findings. Cholangiographic and histologic examinations demonstrated significantly decreased tissue hyperplasia in the AgNP-coated SEMS groups compared with the control group (p < 0.05 for all). There were no differences between the AgNP-coated SEMS groups (p > 0.05 for all). However, in the group coated with the greatest concentration of AgNPs (Group D), submucosal fibrosis was thicker than in the other AgNP-coated groups (p < 0.05 for all). The AgNP-coated metallic stent mesh significantly suppressed stent-induced tissue hyperplasia and biliary sludge formation in the rabbit bile duct. Taken together, the AgNP coating strategy developed in this study could be widely utilized in non-vascular medical devices for anti-bacterial and anti-inflammatory responses.

Original languageEnglish (US)
Article number563
Pages (from-to)1-13
Number of pages13
JournalPharmaceutics
Volume12
Issue number6
DOIs
StatePublished - Jun 2020

Keywords

  • Anti-bacterial response
  • Biliary sludge
  • Self-expandable metallic stent (SEMS)
  • Silver nanoparticles (AgNPs)
  • Tissue hyperplasia

ASJC Scopus subject areas

  • Pharmaceutical Science

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