Metabolomic approach for age discrimination of Panax ginseng using UPLC-Q-Tof MS

Dongho Lee, Nahyun Kim, Kemok Kim, Byeong Yeob Choi, Donghyuk Lee, Yoo Soo Shin, Kyong Hwan Bang, Seon Woo Cha, Jae Won Lee, Hyung Kyoon Choi, Dae Sik Jang

Research output: Contribution to journalArticlepeer-review

99 Scopus citations


An ultraperformance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-Q-Tof MS)-based metabolomic technique was applied for metabolite profiling of 60 Panax ginseng samples aged from 1 to 6 years. Multivariate statistical methods such as principal component analysis and hierarchical clustering analysis were used to compare the derived patterns among the samples. The data set was subsequently applied to various metabolite selection methods for sophisticated classification with the optimal number of metabolites. The results showed variations in accuracy among the classification methods for the samples of different ages, especially for those aged 4, 5, and 6 years. This proposed analytical method coupled with multivariate analysis is fast, accurate, and reliable for discriminating the cultivation ages of P. ginseng samples and is a potential tool to standardize quality control in the P. ginseng industry.

Original languageEnglish (US)
Pages (from-to)10435-10441
Number of pages7
JournalJournal of Agricultural and Food Chemistry
Issue number19
StatePublished - Oct 12 2011
Externally publishedYes


  • Panax ginseng
  • UPLC-Q-Tof MS
  • age discrimination
  • metabolomics
  • multivariate analysis

ASJC Scopus subject areas

  • General Chemistry
  • General Agricultural and Biological Sciences


Dive into the research topics of 'Metabolomic approach for age discrimination of Panax ginseng using UPLC-Q-Tof MS'. Together they form a unique fingerprint.

Cite this