Metabolism in adipose tissue in response to citalopram and trimipramine treatment - An in situ microdialysis study

M. Flechtner-Mors, C. P. Jenkinson, A. Alt, G. Adler, H. H. Ditschuneit

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The intake of antidepressants is often accompanied by weight gain. Antidepressants may influence lipid and carbohydrate metabolism that can result in metabolic changes and obesity. We investigated the effect of citalopram and trimipramine on interstitial glycerol, glucose and lactate concentration and blood flow in subcutaneous adipose tissue of obese subjects by means of the microdialysis technique. In addition, the effect of stimulation with norepinephrine on metabolic response was investigated. Each subject was compared to a control subject matched for BMI and age. Each group comprised 10 subjects. Circulating plasma triglyceride concentrations were higher in drug-treated groups. In subcutaneous adipose tissue, microdialysis experiments revealed a higher and prolonged glycerol release in the presence of norepinephrine, but not under basal conditions. In citalopram treated subjects, basal glucose and lactate concentrations were higher compared with controls or with the trimipramine treated group. Local administration of norepinephrine induced a decrease in glucose levels and an increase in lactate levels, but without significant differences between groups. Local adipose tissue blood flow decreased in control groups following norepinephrine application, but remained constant in the antidepressant groups. In conclusion, citalopram and trimipramine affected glucose and lipid metabolism in adipose tissue and resulted in enhanced release of glycerol and free fatty acids into the circulation.

Original languageEnglish (US)
Pages (from-to)578-586
Number of pages9
JournalJournal of Psychiatric Research
Volume42
Issue number7
DOIs
StatePublished - Jun 2008

Fingerprint

Trimipramine
Citalopram
Microdialysis
Adipose Tissue
Norepinephrine
Glycerol
Antidepressive Agents
Glucose
Lactic Acid
Subcutaneous Fat
Lipid Metabolism
Carbohydrate Metabolism
Nonesterified Fatty Acids
Weight Gain
Triglycerides
Obesity
Control Groups
Pharmaceutical Preparations

Keywords

  • Adipose tissue
  • Antidepressant drugs
  • Lipolysis
  • Microdialysis

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)

Cite this

Metabolism in adipose tissue in response to citalopram and trimipramine treatment - An in situ microdialysis study. / Flechtner-Mors, M.; Jenkinson, C. P.; Alt, A.; Adler, G.; Ditschuneit, H. H.

In: Journal of Psychiatric Research, Vol. 42, No. 7, 06.2008, p. 578-586.

Research output: Contribution to journalArticle

Flechtner-Mors, M. ; Jenkinson, C. P. ; Alt, A. ; Adler, G. ; Ditschuneit, H. H. / Metabolism in adipose tissue in response to citalopram and trimipramine treatment - An in situ microdialysis study. In: Journal of Psychiatric Research. 2008 ; Vol. 42, No. 7. pp. 578-586.
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