Metabolic syndrome: Definition, pathophysiology, and mechanisms

Phillippa J. Miranda; Ralph A. DeFronzo; Robert M. Califf; John R. Guyton

doi:10.1016/j.ahj.2004.07.013

Metabolic syndrome: Definition, pathophysiology, and mechanisms

Phillippa J. Miranda
, Ralph A. DeFronzo
, Robert M. Califf
, John R. Guyton

Division of Diabetes

Research output: Contribution to journal › Article › peer-review

375 Scopus citations

Abstract

Metabolic syndrome is a highly prevalent but under-recognized and undertreated condition. The concurrence of abdominal obesity, borderline hyperglycemia, atherogenic lipoprotein phenotype, and/or hypertension in a patient constitutes a system of linked pathogenesis and high atherogenicity. The complex pathogenetic links involve glucose and fat metabolism, insulin, and a variety of adipocyte-derived hormones and cytokines.

Original language	English (US)
Pages (from-to)	33-45
Number of pages	13
Journal	American Heart Journal
Volume	149
Issue number	1
DOIs	https://doi.org/10.1016/j.ahj.2004.07.013
State	Published - Jan 2005

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.ahj.2004.07.013

Cite this

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title = "Metabolic syndrome: Definition, pathophysiology, and mechanisms",

abstract = "Metabolic syndrome is a highly prevalent but under-recognized and undertreated condition. The concurrence of abdominal obesity, borderline hyperglycemia, atherogenic lipoprotein phenotype, and/or hypertension in a patient constitutes a system of linked pathogenesis and high atherogenicity. The complex pathogenetic links involve glucose and fat metabolism, insulin, and a variety of adipocyte-derived hormones and cytokines.",

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AU - DeFronzo, Ralph A.

AU - Califf, Robert M.

AU - Guyton, John R.

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AB - Metabolic syndrome is a highly prevalent but under-recognized and undertreated condition. The concurrence of abdominal obesity, borderline hyperglycemia, atherogenic lipoprotein phenotype, and/or hypertension in a patient constitutes a system of linked pathogenesis and high atherogenicity. The complex pathogenetic links involve glucose and fat metabolism, insulin, and a variety of adipocyte-derived hormones and cytokines.

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M3 - Article

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Metabolic syndrome: Definition, pathophysiology, and mechanisms

Abstract

ASJC Scopus subject areas

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