Metabolic syndrome: Definition, pathophysiology, and mechanisms

Phillippa J. Miranda, Ralph A. DeFronzo, Robert M. Califf, John R. Guyton

Research output: Contribution to journalArticlepeer-review

329 Scopus citations


Metabolic syndrome is a highly prevalent but under-recognized and undertreated condition. The concurrence of abdominal obesity, borderline hyperglycemia, atherogenic lipoprotein phenotype, and/or hypertension in a patient constitutes a system of linked pathogenesis and high atherogenicity. The complex pathogenetic links involve glucose and fat metabolism, insulin, and a variety of adipocyte-derived hormones and cytokines.

Original languageEnglish (US)
Pages (from-to)33-45
Number of pages13
JournalAmerican Heart Journal
Issue number1
StatePublished - Jan 1 2005

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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