TY - JOUR
T1 - Metabolic syndrome
T2 - Definition, pathophysiology, and mechanisms
AU - Miranda, Phillippa J.
AU - DeFronzo, Ralph A.
AU - Califf, Robert M.
AU - Guyton, John R.
PY - 2005/1
Y1 - 2005/1
N2 - Metabolic syndrome is a highly prevalent but under-recognized and undertreated condition. The concurrence of abdominal obesity, borderline hyperglycemia, atherogenic lipoprotein phenotype, and/or hypertension in a patient constitutes a system of linked pathogenesis and high atherogenicity. The complex pathogenetic links involve glucose and fat metabolism, insulin, and a variety of adipocyte-derived hormones and cytokines.
AB - Metabolic syndrome is a highly prevalent but under-recognized and undertreated condition. The concurrence of abdominal obesity, borderline hyperglycemia, atherogenic lipoprotein phenotype, and/or hypertension in a patient constitutes a system of linked pathogenesis and high atherogenicity. The complex pathogenetic links involve glucose and fat metabolism, insulin, and a variety of adipocyte-derived hormones and cytokines.
UR - http://www.scopus.com/inward/record.url?scp=12344304272&partnerID=8YFLogxK
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U2 - 10.1016/j.ahj.2004.07.013
DO - 10.1016/j.ahj.2004.07.013
M3 - Article
C2 - 15660032
AN - SCOPUS:12344304272
SN - 0002-8703
VL - 149
SP - 33
EP - 45
JO - American Heart Journal
JF - American Heart Journal
IS - 1
ER -