Metabolic Profiling of Blood and Urine for Exploring the Functional Role of the Microbiota in Human Health

Ana F. Diallo, Mark B. Lockwood, Katherine A. Maki, Alexis T. Franks, Abhrarup Roy, Rosario Jaime-Lara, Paule V. Joseph, Wendy A. Henderson, Seon Yoon Chung, Jacqueline McGrath, Stefan J. Green, Anne M. Fink

Research output: Contribution to journalArticle

Abstract

The quantification of metabolites in blood and urine allows nurses to explore new hypotheses about the microbiome. This review summarizes findings from recent studies with a focus on how the state of the science can influence future nursing research initiatives. Metabolomics can advance nursing research by identifying physiologic/pathophysiologic processes underlying patients’ symptoms and can be useful for testing the effects of nursing interventions. To date, metabolomics has been used to study cardiovascular, respiratory, endocrine, autoimmune, and infectious conditions, with research focused on understanding the microbial metabolism of substrates resulting in circulating/excreted biomarkers such as trimethylamine N-oxide. This review provides specific recommendations for the collection of specimens and goals for future studies.

Original languageEnglish (US)
Pages (from-to)449-457
Number of pages9
JournalBiological research for nursing
Volume22
Issue number4
DOIs
StatePublished - Oct 1 2020

Keywords

  • blood
  • cardiovascular
  • diabetes
  • metabolomics
  • microbiome
  • nursing
  • trimethylamine n-oxide
  • urine

ASJC Scopus subject areas

  • Research and Theory

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  • Cite this

    Diallo, A. F., Lockwood, M. B., Maki, K. A., Franks, A. T., Roy, A., Jaime-Lara, R., Joseph, P. V., Henderson, W. A., Chung, S. Y., McGrath, J., Green, S. J., & Fink, A. M. (2020). Metabolic Profiling of Blood and Urine for Exploring the Functional Role of the Microbiota in Human Health. Biological research for nursing, 22(4), 449-457. https://doi.org/10.1177/1099800420941080