Metabolic Profiling of Blood and Urine for Exploring the Functional Role of the Microbiota in Human Health

Ana F. Diallo; Mark B. Lockwood; Katherine A. Maki; Alexis T. Franks; Abhrarup Roy; Rosario Jaime-Lara; Paule V. Joseph; Wendy A. Henderson; Seon Yoon Chung; Jacqueline McGrath; Stefan J. Green; Anne M. Fink

doi:10.1177/1099800420941080

Metabolic Profiling of Blood and Urine for Exploring the Functional Role of the Microbiota in Human Health

Ana F. Diallo, Mark B. Lockwood, Katherine A. Maki, Alexis T. Franks, Abhrarup Roy, Rosario Jaime-Lara, Paule V. Joseph, Wendy A. Henderson, Seon Yoon Chung, Jacqueline McGrath, Stefan J. Green, Anne M. Fink

Office of Faculty Excellence-School of Nursing

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The quantification of metabolites in blood and urine allows nurses to explore new hypotheses about the microbiome. This review summarizes findings from recent studies with a focus on how the state of the science can influence future nursing research initiatives. Metabolomics can advance nursing research by identifying physiologic/pathophysiologic processes underlying patients’ symptoms and can be useful for testing the effects of nursing interventions. To date, metabolomics has been used to study cardiovascular, respiratory, endocrine, autoimmune, and infectious conditions, with research focused on understanding the microbial metabolism of substrates resulting in circulating/excreted biomarkers such as trimethylamine N-oxide. This review provides specific recommendations for the collection of specimens and goals for future studies.

Original language	English (US)
Pages (from-to)	449-457
Number of pages	9
Journal	Biological research for nursing
Volume	22
Issue number	4
DOIs	https://doi.org/10.1177/1099800420941080
State	Published - Oct 1 2020

Keywords

blood
cardiovascular
diabetes
metabolomics
microbiome
nursing
trimethylamine n-oxide
urine

ASJC Scopus subject areas

Research and Theory

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10.1177/1099800420941080

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Diallo, A. F., Lockwood, M. B., Maki, K. A., Franks, A. T., Roy, A., Jaime-Lara, R., Joseph, P. V., Henderson, W. A., Chung, S. Y., McGrath, J., Green, S. J., & Fink, A. M. (2020). Metabolic Profiling of Blood and Urine for Exploring the Functional Role of the Microbiota in Human Health. Biological research for nursing, 22(4), 449-457. https://doi.org/10.1177/1099800420941080

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abstract = "The quantification of metabolites in blood and urine allows nurses to explore new hypotheses about the microbiome. This review summarizes findings from recent studies with a focus on how the state of the science can influence future nursing research initiatives. Metabolomics can advance nursing research by identifying physiologic/pathophysiologic processes underlying patients{\textquoteright} symptoms and can be useful for testing the effects of nursing interventions. To date, metabolomics has been used to study cardiovascular, respiratory, endocrine, autoimmune, and infectious conditions, with research focused on understanding the microbial metabolism of substrates resulting in circulating/excreted biomarkers such as trimethylamine N-oxide. This review provides specific recommendations for the collection of specimens and goals for future studies.",

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AU - Diallo, Ana F.

AU - Lockwood, Mark B.

AU - Maki, Katherine A.

AU - Franks, Alexis T.

AU - Roy, Abhrarup

AU - Jaime-Lara, Rosario

AU - Joseph, Paule V.

AU - Henderson, Wendy A.

AU - Chung, Seon Yoon

AU - McGrath, Jacqueline

AU - Green, Stefan J.

AU - Fink, Anne M.

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AB - The quantification of metabolites in blood and urine allows nurses to explore new hypotheses about the microbiome. This review summarizes findings from recent studies with a focus on how the state of the science can influence future nursing research initiatives. Metabolomics can advance nursing research by identifying physiologic/pathophysiologic processes underlying patients’ symptoms and can be useful for testing the effects of nursing interventions. To date, metabolomics has been used to study cardiovascular, respiratory, endocrine, autoimmune, and infectious conditions, with research focused on understanding the microbial metabolism of substrates resulting in circulating/excreted biomarkers such as trimethylamine N-oxide. This review provides specific recommendations for the collection of specimens and goals for future studies.

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KW - diabetes

KW - metabolomics

KW - microbiome

KW - nursing

KW - trimethylamine n-oxide

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Metabolic Profiling of Blood and Urine for Exploring the Functional Role of the Microbiota in Human Health

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Keywords

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