Metabolic profiles of rats of different ages

Stephen C. Gates; Stephen J. Provancal; James W. Webb; Arlan Richardson

doi:10.1016/0531-5565(84)90023-8

Metabolic profiles of rats of different ages

Stephen C. Gates, Stephen J. Provancal, James W. Webb, Arlan Richardson

Barshop Institute

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Urine samples from 6- to 31-month-old male Fischer F344 rats were analyzed using a high performance liquid chromatograph and a unique computer-based data analysis and quality control system in order to discover substances that could be used as markers in the aging process. Metabolic profiles of the organic acids from these urines yielded 42 peaks whose areas could be measured reliably. Of the 42 peaks, 10 were found by analysis of variance to vary significantly (p < 0.05) with age. Rats from the four ages could also be distinguished using a multivariate statistic (discriminant analysis).

Original language	English (US)
Pages (from-to)	279-288
Number of pages	10
Journal	Experimental Gerontology
Volume	19
Issue number	4
DOIs	https://doi.org/10.1016/0531-5565(84)90023-8
State	Published - 1984

ASJC Scopus subject areas

Biochemistry
Aging
Molecular Biology
Genetics
Endocrinology
Cell Biology

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title = "Metabolic profiles of rats of different ages",

abstract = "Urine samples from 6- to 31-month-old male Fischer F344 rats were analyzed using a high performance liquid chromatograph and a unique computer-based data analysis and quality control system in order to discover substances that could be used as markers in the aging process. Metabolic profiles of the organic acids from these urines yielded 42 peaks whose areas could be measured reliably. Of the 42 peaks, 10 were found by analysis of variance to vary significantly (p < 0.05) with age. Rats from the four ages could also be distinguished using a multivariate statistic (discriminant analysis).",

author = "Gates, {Stephen C.} and Provancal, {Stephen J.} and Webb, {James W.} and Arlan Richardson",

note = "Funding Information: Acknowledgement-This research was supported in part from grant AG01548 to A. Richardson by the National Institutes of Health, and in part by support from Illinois State University.",

year = "1984",

doi = "10.1016/0531-5565(84)90023-8",

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pages = "279--288",

journal = "Experimental Gerontology",

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T1 - Metabolic profiles of rats of different ages

AU - Gates, Stephen C.

AU - Provancal, Stephen J.

AU - Webb, James W.

AU - Richardson, Arlan

N1 - Funding Information: Acknowledgement-This research was supported in part from grant AG01548 to A. Richardson by the National Institutes of Health, and in part by support from Illinois State University.

PY - 1984

Y1 - 1984

N2 - Urine samples from 6- to 31-month-old male Fischer F344 rats were analyzed using a high performance liquid chromatograph and a unique computer-based data analysis and quality control system in order to discover substances that could be used as markers in the aging process. Metabolic profiles of the organic acids from these urines yielded 42 peaks whose areas could be measured reliably. Of the 42 peaks, 10 were found by analysis of variance to vary significantly (p < 0.05) with age. Rats from the four ages could also be distinguished using a multivariate statistic (discriminant analysis).

AB - Urine samples from 6- to 31-month-old male Fischer F344 rats were analyzed using a high performance liquid chromatograph and a unique computer-based data analysis and quality control system in order to discover substances that could be used as markers in the aging process. Metabolic profiles of the organic acids from these urines yielded 42 peaks whose areas could be measured reliably. Of the 42 peaks, 10 were found by analysis of variance to vary significantly (p < 0.05) with age. Rats from the four ages could also be distinguished using a multivariate statistic (discriminant analysis).

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JO - Experimental Gerontology

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SN - 0531-5565

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Metabolic profiles of rats of different ages

Abstract

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