Metabolic profiles of rats of different ages

Stephen C. Gates, Stephen J. Provancal, James W. Webb, Arlan Richardson

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Urine samples from 6- to 31-month-old male Fischer F344 rats were analyzed using a high performance liquid chromatograph and a unique computer-based data analysis and quality control system in order to discover substances that could be used as markers in the aging process. Metabolic profiles of the organic acids from these urines yielded 42 peaks whose areas could be measured reliably. Of the 42 peaks, 10 were found by analysis of variance to vary significantly (p < 0.05) with age. Rats from the four ages could also be distinguished using a multivariate statistic (discriminant analysis).

Original languageEnglish (US)
Pages (from-to)279-288
Number of pages10
JournalExperimental Gerontology
Issue number4
StatePublished - 1984
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Aging
  • Molecular Biology
  • Genetics
  • Endocrinology
  • Cell Biology


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