Metabolic factors that contribute to lupus pathogenesis

Wei Li, Ramya Sivakumar, Anton A. Titov, Seung Chul Choi, Laurence Morel

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease in which organ damage is mediated by pathogenic autoantibodies directed against nucleic acids and protein complexes. Studies in SLE patients and in mouse models of lupus have implicated virtually every cell type in the immune system in the induction or amplification of the autoimmune response as well as the promotion of an inflammatory environment that aggravates tissue injury. Here, we review the contribution of CD4+ T cells, B cells, and myeloid cells to lupus pathogenesis and then discuss alterations in the metabolism of these cells that may contribute to disease, given the recent advances in the field of immunometabolism.

Original languageEnglish (US)
Pages (from-to)75-98
Number of pages24
JournalCritical Reviews in Immunology
Volume36
Issue number1
DOIs
StatePublished - 2016
Externally publishedYes

Keywords

  • Autoimmunity
  • B cells
  • Immunometabolism
  • Lupus
  • Myeloid cells
  • T cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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