Metabolic consequences of the early onset of obesity in common marmoset monkeys

Michael L. Power, Corinna N. Ross, Jay Schulkin, Toni E. Ziegler, Suzette D. Tardif

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Objective The common marmoset as a model of early obesity was assessed. The hypotheses that juvenile marmosets with excess adipose tissue will display higher fasting glucose, decreased insulin sensitivity, and decreased ability to clear glucose from the blood stream were tested. Design and Methods Normal and obese (body fat > 14%) common marmoset infants (N = 39) were followed up from birth until 1 year. Body fat was measured by quantitative magnetic resonance. Circulating glucose was measured by glucometer and insulin, adiponectin, and leptin by commercial assays. The quantitative insulin sensitivity check index (QUICKI; a measure of insulin sensitivity) was calculated for subjects with fasting glucose and insulin measures. Oral glucose tolerance tests (OGTTs) were conducted at 12 months on 35 subjects. Results At 6 months, obese subjects already had significantly lower insulin sensitivity (mean QUICKI = 0.378 ± 0.029 vs. 0.525 ± 0.019, N = 11, P = 0.003). By 12 months, obese subjects also had higher fasting glucose (129.3 ± 9.1 mg/dL vs. 106.1 ± 6.5 mg/dL, P = 0.042), and circulating adiponectin tended to be lower (P = 0.057). Leptin was associated with percent body fat; however, birth weight also influenced circulating leptin. The OGTT results demonstrated that obese animals had a decreased ability to clear glucose. Conclusions Early-onset obesity in marmosets results in impaired glucose homeostasis by 1 year.

Original languageEnglish (US)
JournalObesity
Volume21
Issue number12
DOIs
StatePublished - Dec 2013

Fingerprint

Callithrix
Haplorhini
Obesity
Glucose
Insulin Resistance
Adipose Tissue
Leptin
Fasting
Aptitude
Adiponectin
Glucose Tolerance Test
Insulin
Birth Weight
Blood Glucose
Homeostasis
Magnetic Resonance Spectroscopy
Parturition

ASJC Scopus subject areas

  • Endocrinology
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Power, M. L., Ross, C. N., Schulkin, J., Ziegler, T. E., & Tardif, S. D. (2013). Metabolic consequences of the early onset of obesity in common marmoset monkeys. Obesity, 21(12). https://doi.org/10.1002/oby.20462

Metabolic consequences of the early onset of obesity in common marmoset monkeys. / Power, Michael L.; Ross, Corinna N.; Schulkin, Jay; Ziegler, Toni E.; Tardif, Suzette D.

In: Obesity, Vol. 21, No. 12, 12.2013.

Research output: Contribution to journalArticle

Power, ML, Ross, CN, Schulkin, J, Ziegler, TE & Tardif, SD 2013, 'Metabolic consequences of the early onset of obesity in common marmoset monkeys', Obesity, vol. 21, no. 12. https://doi.org/10.1002/oby.20462
Power, Michael L. ; Ross, Corinna N. ; Schulkin, Jay ; Ziegler, Toni E. ; Tardif, Suzette D. / Metabolic consequences of the early onset of obesity in common marmoset monkeys. In: Obesity. 2013 ; Vol. 21, No. 12.
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