Metabolic activation of DMH by colonic microsomes: A process influenced by type of dietary fat

Michael J Wargovich, I. C. Felkner

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

A study was conducted to determine whether 1,2-dimethylhydrazine (DMH), a potent colon carcinogen, is activated to a more potent mutagen by the drug-metabolizing system of the colonic mucosa and to determine the extent to which this metabolism is modified by lipids in the diet. DMH-treated rats fed a diet enriched with 10% corn oil exhibited markedly elevated colonic enzyme levels for mutagen production. This diet also produced the greatest number of animals with colon tumors, when compared with diets containing other levels and sources of lipid. The potential risk of a diet in which unsaturated fat is the sole source of lipid is underlined.

Original languageEnglish (US)
Pages (from-to)146-153
Number of pages8
JournalNutrition and Cancer
Volume4
Issue number2
StatePublished - 1982
Externally publishedYes

Fingerprint

Dimethylhydrazines
Dietary Fats
microsomes
Microsomes
dietary fat
Diet
diet
Mutagens
Lipids
colon
Colon
lipids
Unsaturated Fats
1,2-dimethylhydrazine
1,2-Dimethylhydrazine
Corn Oil
carcinogens
corn oil
Carcinogens
mucosa

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)
  • Oncology

Cite this

Metabolic activation of DMH by colonic microsomes : A process influenced by type of dietary fat. / Wargovich, Michael J; Felkner, I. C.

In: Nutrition and Cancer, Vol. 4, No. 2, 1982, p. 146-153.

Research output: Contribution to journalArticle

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