Metabolic Activation Of Dmh By Colonic Microsomes: A Process Influenced By Type Of Dietary Fat

Michael J. Wargovich

doi:10.1080/01635588209513750

Metabolic Activation Of Dmh By Colonic Microsomes: A Process Influenced By Type Of Dietary Fat

Michael J. Wargovich

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

A study was conducted to determine whether 1, 2-dimethylhydrazine (DMH), a potent colon carcinogen, is activated to a more potent mutagen by the drug-metabolizing system of the colonic mucosa and to determine the extent to which this metabolism is modified by lipids in the diet. DMH-treated rats fed a diet enriched with 10% corn oil exhibited markedly elevated colonic enzyme levels for mutagen production. This diet also produced the greatest number of animals with colon tumors, when compared with diets containing other levels and sources of lipid. The potential risk of a diet in which unsaturated fat is the sole source of lipid is underlined.

Original language	English (US)
Pages (from-to)	146-153
Number of pages	8
Journal	Nutrition and Cancer
Volume	4
Issue number	2
DOIs	https://doi.org/10.1080/01635588209513750
State	Published - Jan 1 1982
Externally published	Yes

ASJC Scopus subject areas

Medicine (miscellaneous)
Oncology
Nutrition and Dietetics
Cancer Research

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