Abstract
A study was conducted to determine whether 1,2-dimethylhydrazine (DMH), a potent colon carcinogen, is activated to a more potent mutagen by the drug-metabolizing system of the colonic mucosa and to determine the extent to which this metabolism is modified by lipids in the diet. DMH-treated rats fed a diet enriched with 10% corn oil exhibited markedly elevated colonic enzyme levels for mutagen production. This diet also produced the greatest number of animals with colon tumors, when compared with diets containing other levels and sources of lipid. The potential risk of a diet in which unsaturated fat is the sole source of lipid is underlined.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 146-153 |
| Number of pages | 8 |
| Journal | Nutrition and Cancer |
| Volume | 4 |
| Issue number | 2 |
| State | Published - 1982 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Food Science
- Medicine (miscellaneous)
- Oncology
Cite this
Metabolic activation of DMH by colonic microsomes : A process influenced by type of dietary fat. / Wargovich, Michael J; Felkner, I. C.
In: Nutrition and Cancer, Vol. 4, No. 2, 1982, p. 146-153.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Metabolic activation of DMH by colonic microsomes
T2 - A process influenced by type of dietary fat
AU - Wargovich, Michael J
AU - Felkner, I. C.
PY - 1982
Y1 - 1982
N2 - A study was conducted to determine whether 1,2-dimethylhydrazine (DMH), a potent colon carcinogen, is activated to a more potent mutagen by the drug-metabolizing system of the colonic mucosa and to determine the extent to which this metabolism is modified by lipids in the diet. DMH-treated rats fed a diet enriched with 10% corn oil exhibited markedly elevated colonic enzyme levels for mutagen production. This diet also produced the greatest number of animals with colon tumors, when compared with diets containing other levels and sources of lipid. The potential risk of a diet in which unsaturated fat is the sole source of lipid is underlined.
AB - A study was conducted to determine whether 1,2-dimethylhydrazine (DMH), a potent colon carcinogen, is activated to a more potent mutagen by the drug-metabolizing system of the colonic mucosa and to determine the extent to which this metabolism is modified by lipids in the diet. DMH-treated rats fed a diet enriched with 10% corn oil exhibited markedly elevated colonic enzyme levels for mutagen production. This diet also produced the greatest number of animals with colon tumors, when compared with diets containing other levels and sources of lipid. The potential risk of a diet in which unsaturated fat is the sole source of lipid is underlined.
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UR - http://www.scopus.com/inward/citedby.url?scp=0020286306&partnerID=8YFLogxK
M3 - Article
C2 - 6819546
AN - SCOPUS:0020286306
VL - 4
SP - 146
EP - 153
JO - Nutrition and Cancer
JF - Nutrition and Cancer
SN - 0163-5581
IS - 2
ER -