Metabolic Activation Of Dmh By Colonic Microsomes: A Process Influenced By Type Of Dietary Fat

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

A study was conducted to determine whether 1, 2-dimethylhydrazine (DMH), a potent colon carcinogen, is activated to a more potent mutagen by the drug-metabolizing system of the colonic mucosa and to determine the extent to which this metabolism is modified by lipids in the diet. DMH-treated rats fed a diet enriched with 10% corn oil exhibited markedly elevated colonic enzyme levels for mutagen production. This diet also produced the greatest number of animals with colon tumors, when compared with diets containing other levels and sources of lipid. The potential risk of a diet in which unsaturated fat is the sole source of lipid is underlined.

Original languageEnglish (US)
Pages (from-to)146-153
Number of pages8
JournalNutrition and Cancer
Volume4
Issue number2
DOIs
StatePublished - Jan 1 1982
Externally publishedYes

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ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Oncology
  • Nutrition and Dietetics
  • Cancer Research

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