Abstract
1. The ability of homogenates from kidney tissue of 4- to 26-month-old male Fischer F344 rats, 6- to 30-month-old male Sprague-Dawley rats, and 5- to 30-month-old male C57 BL/6J mice to metabolically activate the chemical procarcinogens 2-aminofluorene and aflatoxin B1 to mutagens was measured using the Ames Salmonella/microsome test. 2. The conversion of 2-aminofluorene to mutagenic compounds by kidney homogenates from Fischer F344 and Sprague-Dawley rats and C57 BL/6J mice decreased 35-50% with increasing age. 3. An age-related decrease (50-65%) in the ability of kidney homogenates from Fischer F344 rats and C57 BL/6J mice to convert aflatoxin B1 to mutagenic compounds was also observed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 435-438 |
| Number of pages | 4 |
| Journal | Comparative Biochemistry and Physiology. Part C, Comparative |
| Volume | 73 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1982 |
ASJC Scopus subject areas
- Immunology
- Pharmacology
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Sutter, M. A., Chernesky, P., Jayaraj, A., & Richardson, A. (1982). Metabolic activation of chemical carcinogens by kidney from rats and mice of various ages. Comparative Biochemistry and Physiology. Part C, Comparative, 73(2), 435-438. https://doi.org/10.1016/0306-4492(82)90149-6