Metabolic activation of chemical carcinogens by kidney from rats and mice of various ages

Mary Alanna Sutter; Patrick Chernesky; Andrew Jayaraj; Arlan Richardson

doi:10.1016/0306-4492(82)90149-6

Metabolic activation of chemical carcinogens by kidney from rats and mice of various ages

Mary Alanna Sutter, Patrick Chernesky, Andrew Jayaraj, Arlan Richardson

Barshop Institute

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

1. The ability of homogenates from kidney tissue of 4- to 26-month-old male Fischer F344 rats, 6- to 30-month-old male Sprague-Dawley rats, and 5- to 30-month-old male C57 BL/6J mice to metabolically activate the chemical procarcinogens 2-aminofluorene and aflatoxin B₁ to mutagens was measured using the Ames Salmonella/microsome test. 2. The conversion of 2-aminofluorene to mutagenic compounds by kidney homogenates from Fischer F344 and Sprague-Dawley rats and C57 BL/6J mice decreased 35-50% with increasing age. 3. An age-related decrease (50-65%) in the ability of kidney homogenates from Fischer F344 rats and C57 BL/6J mice to convert aflatoxin B₁ to mutagenic compounds was also observed.

Original language	English (US)
Pages (from-to)	435-438
Number of pages	4
Journal	Comparative Biochemistry and Physiology. Part C, Comparative
Volume	73
Issue number	2
DOIs	https://doi.org/10.1016/0306-4492(82)90149-6
State	Published - 1982

ASJC Scopus subject areas

Immunology
Pharmacology

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@article{8c24739634a147059b93380cb85e9bf5,

title = "Metabolic activation of chemical carcinogens by kidney from rats and mice of various ages",

abstract = "1. The ability of homogenates from kidney tissue of 4- to 26-month-old male Fischer F344 rats, 6- to 30-month-old male Sprague-Dawley rats, and 5- to 30-month-old male C57 BL/6J mice to metabolically activate the chemical procarcinogens 2-aminofluorene and aflatoxin B1 to mutagens was measured using the Ames Salmonella/microsome test. 2. The conversion of 2-aminofluorene to mutagenic compounds by kidney homogenates from Fischer F344 and Sprague-Dawley rats and C57 BL/6J mice decreased 35-50% with increasing age. 3. An age-related decrease (50-65%) in the ability of kidney homogenates from Fischer F344 rats and C57 BL/6J mice to convert aflatoxin B1 to mutagenic compounds was also observed.",

author = "Sutter, {Mary Alanna} and Patrick Chernesky and Andrew Jayaraj and Arlan Richardson",

note = "Funding Information: Acknowledgements--This investigation was supported by PHS Grant number 5 ROI CA 24856 awarded by the National Cancer Institute, DHHS.",

year = "1982",

doi = "10.1016/0306-4492(82)90149-6",

language = "English (US)",

volume = "73",

pages = "435--438",

journal = "Comparative biochemistry and physiology. C: Comparative pharmacology",

issn = "0306-4492",

publisher = "Elsevier BV",

number = "2",

}

TY - JOUR

T1 - Metabolic activation of chemical carcinogens by kidney from rats and mice of various ages

AU - Sutter, Mary Alanna

AU - Chernesky, Patrick

AU - Jayaraj, Andrew

AU - Richardson, Arlan

N1 - Funding Information: Acknowledgements--This investigation was supported by PHS Grant number 5 ROI CA 24856 awarded by the National Cancer Institute, DHHS.

PY - 1982

Y1 - 1982

N2 - 1. The ability of homogenates from kidney tissue of 4- to 26-month-old male Fischer F344 rats, 6- to 30-month-old male Sprague-Dawley rats, and 5- to 30-month-old male C57 BL/6J mice to metabolically activate the chemical procarcinogens 2-aminofluorene and aflatoxin B1 to mutagens was measured using the Ames Salmonella/microsome test. 2. The conversion of 2-aminofluorene to mutagenic compounds by kidney homogenates from Fischer F344 and Sprague-Dawley rats and C57 BL/6J mice decreased 35-50% with increasing age. 3. An age-related decrease (50-65%) in the ability of kidney homogenates from Fischer F344 rats and C57 BL/6J mice to convert aflatoxin B1 to mutagenic compounds was also observed.

AB - 1. The ability of homogenates from kidney tissue of 4- to 26-month-old male Fischer F344 rats, 6- to 30-month-old male Sprague-Dawley rats, and 5- to 30-month-old male C57 BL/6J mice to metabolically activate the chemical procarcinogens 2-aminofluorene and aflatoxin B1 to mutagens was measured using the Ames Salmonella/microsome test. 2. The conversion of 2-aminofluorene to mutagenic compounds by kidney homogenates from Fischer F344 and Sprague-Dawley rats and C57 BL/6J mice decreased 35-50% with increasing age. 3. An age-related decrease (50-65%) in the ability of kidney homogenates from Fischer F344 rats and C57 BL/6J mice to convert aflatoxin B1 to mutagenic compounds was also observed.

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U2 - 10.1016/0306-4492(82)90149-6

DO - 10.1016/0306-4492(82)90149-6

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AN - SCOPUS:0020364375

VL - 73

SP - 435

EP - 438

JO - Comparative biochemistry and physiology. C: Comparative pharmacology

JF - Comparative biochemistry and physiology. C: Comparative pharmacology

SN - 0306-4492

IS - 2

ER -

Metabolic activation of chemical carcinogens by kidney from rats and mice of various ages

Abstract

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