Metabolic activation of chemical carcinogens by kidney from rats and mice of various ages

Mary Alanna Sutter, Patrick Chernesky, Andrew Jayaraj, Arlan Richardson

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

1. The ability of homogenates from kidney tissue of 4- to 26-month-old male Fischer F344 rats, 6- to 30-month-old male Sprague-Dawley rats, and 5- to 30-month-old male C57 BL/6J mice to metabolically activate the chemical procarcinogens 2-aminofluorene and aflatoxin B1 to mutagens was measured using the Ames Salmonella/microsome test. 2. The conversion of 2-aminofluorene to mutagenic compounds by kidney homogenates from Fischer F344 and Sprague-Dawley rats and C57 BL/6J mice decreased 35-50% with increasing age. 3. An age-related decrease (50-65%) in the ability of kidney homogenates from Fischer F344 rats and C57 BL/6J mice to convert aflatoxin B1 to mutagenic compounds was also observed.

Original languageEnglish (US)
Pages (from-to)435-438
Number of pages4
JournalComparative Biochemistry and Physiology. Part C, Comparative
Volume73
Issue number2
DOIs
StatePublished - 1982

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

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