Meta-analysis of five genome-wide linkage studies for body mass index reveals significant evidence for linkage to chromosome 8p

L. Johnson, A. Luke, H. W. Deng, B. D. Mitchell, A. G. Comuzzie, S. A. Cole, J. Blangero, M. Perola, M. Dawn Teare

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

OBJECTIVE: To perform a meta-analysis of genome-wide linkage scans using body mass index (BMI) to identify genetic loci predisposing to obesity. DATA: A total of 13 published genome scans on obesity have used BMI as their primary end point. Five of these 13 groups agreed to provide detailed results from their scans that were required for a meta-analysis. Collectively, these five studies included a total of 2814 individuals from 505 families. METHODS: The results of the five studies were analysed using the GSMA (genome scans meta-analysis) method. RESULTS: The analysis revealed significant evidence for linkage of the quantitative phenotype BMI to 8p (P < 0.0005).

Original languageEnglish (US)
Pages (from-to)413-419
Number of pages7
JournalInternational Journal of Obesity
Volume29
Issue number4
DOIs
StatePublished - Apr 2005
Externally publishedYes

Keywords

  • BMI
  • Genome scan
  • Meta-analysis

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

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