Meta-analysis of five genome-wide linkage studies for body mass index reveals significant evidence for linkage to chromosome 8p

L. Johnson, A. Luke, H. W. Deng, B. D. Mitchell, A. G. Comuzzie, S. A. Cole, J. Blangero, M. Perola, M. Dawn Teare

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

OBJECTIVE: To perform a meta-analysis of genome-wide linkage scans using body mass index (BMI) to identify genetic loci predisposing to obesity. DATA: A total of 13 published genome scans on obesity have used BMI as their primary end point. Five of these 13 groups agreed to provide detailed results from their scans that were required for a meta-analysis. Collectively, these five studies included a total of 2814 individuals from 505 families. METHODS: The results of the five studies were analysed using the GSMA (genome scans meta-analysis) method. RESULTS: The analysis revealed significant evidence for linkage of the quantitative phenotype BMI to 8p (P < 0.0005).

Original languageEnglish (US)
Pages (from-to)413-419
Number of pages7
JournalInternational Journal of Obesity
Volume29
Issue number4
DOIs
StatePublished - Apr 2005
Externally publishedYes

Fingerprint

meta-analysis
linkage (genetics)
body mass index
Meta-Analysis
Body Mass Index
Chromosomes
Genome
chromosomes
genome
obesity
Obesity
Genetic Loci
Phenotype
phenotype
loci
methodology

Keywords

  • BMI
  • Genome scan
  • Meta-analysis

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Public Health, Environmental and Occupational Health
  • Endocrinology
  • Food Science
  • Endocrinology, Diabetes and Metabolism

Cite this

Meta-analysis of five genome-wide linkage studies for body mass index reveals significant evidence for linkage to chromosome 8p. / Johnson, L.; Luke, A.; Deng, H. W.; Mitchell, B. D.; Comuzzie, A. G.; Cole, S. A.; Blangero, J.; Perola, M.; Teare, M. Dawn.

In: International Journal of Obesity, Vol. 29, No. 4, 04.2005, p. 413-419.

Research output: Contribution to journalArticle

Johnson, L, Luke, A, Deng, HW, Mitchell, BD, Comuzzie, AG, Cole, SA, Blangero, J, Perola, M & Teare, MD 2005, 'Meta-analysis of five genome-wide linkage studies for body mass index reveals significant evidence for linkage to chromosome 8p', International Journal of Obesity, vol. 29, no. 4, pp. 413-419. https://doi.org/10.1038/sj.ijo.0802817
Johnson, L. ; Luke, A. ; Deng, H. W. ; Mitchell, B. D. ; Comuzzie, A. G. ; Cole, S. A. ; Blangero, J. ; Perola, M. ; Teare, M. Dawn. / Meta-analysis of five genome-wide linkage studies for body mass index reveals significant evidence for linkage to chromosome 8p. In: International Journal of Obesity. 2005 ; Vol. 29, No. 4. pp. 413-419.
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