Meta-analysis of five genome-wide linkage studies for body mass index reveals significant evidence for linkage to chromosome 8p

L. Johnson, A. Luke, H. W. Deng, B. D. Mitchell, A. G. Comuzzie, S. A. Cole, J. Blangero, M. Perola, M. Dawn Teare

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    14 Scopus citations

    Abstract

    OBJECTIVE: To perform a meta-analysis of genome-wide linkage scans using body mass index (BMI) to identify genetic loci predisposing to obesity. DATA: A total of 13 published genome scans on obesity have used BMI as their primary end point. Five of these 13 groups agreed to provide detailed results from their scans that were required for a meta-analysis. Collectively, these five studies included a total of 2814 individuals from 505 families. METHODS: The results of the five studies were analysed using the GSMA (genome scans meta-analysis) method. RESULTS: The analysis revealed significant evidence for linkage of the quantitative phenotype BMI to 8p (P < 0.0005).

    Original languageEnglish (US)
    Pages (from-to)413-419
    Number of pages7
    JournalInternational Journal of Obesity
    Volume29
    Issue number4
    DOIs
    StatePublished - Apr 2005

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    Keywords

    • BMI
    • Genome scan
    • Meta-analysis

    ASJC Scopus subject areas

    • Medicine (miscellaneous)
    • Endocrinology, Diabetes and Metabolism
    • Nutrition and Dietetics

    Cite this

    Johnson, L., Luke, A., Deng, H. W., Mitchell, B. D., Comuzzie, A. G., Cole, S. A., Blangero, J., Perola, M., & Teare, M. D. (2005). Meta-analysis of five genome-wide linkage studies for body mass index reveals significant evidence for linkage to chromosome 8p. International Journal of Obesity, 29(4), 413-419. https://doi.org/10.1038/sj.ijo.0802817