Mesocestoides corti intracranial infection as a murine model for neurocysticercosis

Jorge I. Alvarez, Bibhuti B. Mishra, Uma Mahesh Gundra, Pramod K. Mishra, Judy M. Teale

Research output: Contribution to journalReview articlepeer-review

37 Scopus citations

Abstract

SUMMARY Neurocysticercosis (NCC) is the most common parasitic disease of the central nervous system (CNS) caused by the larval form of the tapeworm Taenia solium. NCC has a long asymptomatic period with little or no inflammation, and the sequential progression to symptomatic NCC depends upon the intense inflammation associated with degeneration of larvae. The mechanisms involved in these progressive events are difficult to study in human patients. Thus it was necessary to develop an experimental model that replicated NCC. In this review, we describe studies of a murine model of NCC in terms of the release/secretion of parasite antigens, immune responses elicited within the CNS environment and subsequent pathogenesis. In particular, the kinetics of leukocyte subsets infiltrating into the brain are discussed in the context of disruption of the CNS barriers at distinct anatomical sites and the mechanisms contributing to these processes. In addition, production of various inflammatory mediators and the mechanisms involved in their induction by the Toll-like receptor signaling pathway are described. Overall, the knowledge gained from the mouse model of NCC has provided new insights for understanding the kinetics of events contributing to different stages of NCC and should aid in the formulation of more effective therapeutic approaches.

Original languageEnglish (US)
Pages (from-to)359-372
Number of pages14
JournalParasitology
Volume137
Issue number3
DOIs
StatePublished - Mar 2010

Keywords

  • Blood Brain Barrier
  • Immunomodulation
  • Mesocestoides corti
  • Neurocysticercosis
  • Neuroinflammation
  • Taenia solium
  • Toll-like receptors

ASJC Scopus subject areas

  • Parasitology
  • Animal Science and Zoology
  • Infectious Diseases

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