Mesenchymal cell response to biomaterials is modulated by their maturation state in their lineage

Barbara D. Boyan, Christoph H. Lohmann, David D. Dean, Lynda F. Bonewald, David L. Cochran, Zvi Schwartz

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Osteoblasts and chondrocytes respond to material surface roughness as well as to chemical composition. The effect of these surface characteristics on chondrocyte response depends on the state of endochondral maturation of the cells. Here, we present data showing that the maturation state of cells in the osteoblastic lineage is also an important variable in their response to material surfaces. Fetal rat calvarial cells (FRCs), MG63 human osteoblast-like osteosarcoma cells, mouse OCT-1 mature osteoblast-like cells, and mouse MLO-Y4 osteocyte-like cells were cultured on cpTi disks with Ra's of 0.5, 4 and 5 mm. Cells expressed their differentiated phenotypes only on rough surfaces in a roughness-dependent manner.

Original languageEnglish (US)
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
PublisherIEEE
Number of pages1
ISBN (Print)0780356756
StatePublished - Dec 1 1999
EventProceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS) - Atlanta, GA, USA
Duration: Oct 13 1999Oct 16 1999

Publication series

NameAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume2
ISSN (Print)0589-1019

Other

OtherProceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS)
CityAtlanta, GA, USA
Period10/13/9910/16/99

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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  • Cite this

    Boyan, B. D., Lohmann, C. H., Dean, D. D., Bonewald, L. F., Cochran, D. L., & Schwartz, Z. (1999). Mesenchymal cell response to biomaterials is modulated by their maturation state in their lineage. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings (Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings; Vol. 2). IEEE.