Menstrual cyclicity has a profound effect on glucose homeostasis

M. P. Diamond, D. C. Simonson, Ralph A Defronzo

Research output: Contribution to journalArticle

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Abstract

Results from oral glucose tolerance tests have frequently demonstrated a deterioration in glucose metabolism during the luteal phase of the menstrual cycle. To examine this issue further, eight women underwent both midfollicular (days 3 to 10) and midluteal (days 20 to 25) phase hyperglycemic clamp studies (+125 mg glucose/dl) after an overnight fast. Glucose levels rose from 83 ± 1 to 207 ± 2 and 87 ± 1 to 207 ± 2 mg/dl, respectively, during the follicular and luteal phases. The basal (6 ± 1 versus 7 ± 1 μU/ml) and glucose-stimulated (42 ± 5 versus 43 ± 6 μU/ml) insulin responses were similar in the follicular and luteal studies. However, glucose uptake was significantly higher during the follicular versus the luteal phase (10.99 ± 0.97 versus 6.93 ± 0.37 mg/kg-min; P < 0.01), as was the ratio of glucose uptake to insulin concentration (30.0 ± 5.5 versus 19.7 ± 3.7, P < 0.01). The authors conclude that: (1) Glucose metabolism is impaired in the luteal phase of the menstrual cycle; (2) This defect cannot be explained by differences in the plasma insulin response; and (3) This impairment in the ability to promote glucose uptake under hyperglycemic conditions suggests a defect in the mass action effect of glucose per se.

Original languageEnglish (US)
Pages (from-to)204-208
Number of pages5
JournalFertility and Sterility
Volume52
Issue number2
StatePublished - 1989
Externally publishedYes

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Periodicity
Homeostasis
Glucose
Luteal Phase
Insulin
Follicular Phase
Corpus Luteum
Glucose Tolerance Test

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Menstrual cyclicity has a profound effect on glucose homeostasis. / Diamond, M. P.; Simonson, D. C.; Defronzo, Ralph A.

In: Fertility and Sterility, Vol. 52, No. 2, 1989, p. 204-208.

Research output: Contribution to journalArticle

Diamond, M. P. ; Simonson, D. C. ; Defronzo, Ralph A. / Menstrual cyclicity has a profound effect on glucose homeostasis. In: Fertility and Sterility. 1989 ; Vol. 52, No. 2. pp. 204-208.
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