Meningeal involvement in early stage chronic lymphocytic leukemia

Joseph Cash, Kim M. Fehir, Marilyn S. Pollack

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


Two patients with early stage chronic lymphocytic leukemia were found to have meningeal involvement. The diagnosis was confirmed by cerebral spinal fluid cytology in the first patient and by flow cytometric analysis in the second patient. Both patients responded well to intrathecal chemotherapy and cranial irradiation. Central nervous system infiltration by tumor cells has rarely been described in chronic lymphocytic leukemia but must be considered in all patients regardless of stage who present with lethargy, dementia, or focal neurologic signs. Cancer 59:798‐800, 1987.

Original languageEnglish (US)
Pages (from-to)798-800
Number of pages3
Issue number4
StatePublished - Feb 15 1987
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


Dive into the research topics of 'Meningeal involvement in early stage chronic lymphocytic leukemia'. Together they form a unique fingerprint.

Cite this