DNA double-strand breaks (DSBs) pose a special challenge for cells in the maintenance of genome stability. In eukaryotes, the removal of DSBs is mediated by two major pathways: homologous recombination (HR) and nonhomologous endjoining (NHEJ). Capitalizing on existing genetic frameworks, biochemical reconstitution studies have begun to yield insights into the mechanistic underpinnings of these DNA repair reactions.
|Original language||English (US)|
|Title of host publication||Progress in Nucleic Acid Research and Molecular Biology|
|Number of pages||43|
|State||Published - Dec 1 2003|
|Name||Progress in Nucleic Acid Research and Molecular Biology|
ASJC Scopus subject areas
- Molecular Biology