Mending the Break: Two DNA Double-Strand Break Repair Machines in Eukaryotes

Lumir Krejci, Ling Chen, Stephen Van Komen, Patrick Sung, Alan Tomkinson

Research output: Chapter in Book/Report/Conference proceedingChapter

55 Scopus citations

Abstract

DNA double-strand breaks (DSBs) pose a special challenge for cells in the maintenance of genome stability. In eukaryotes, the removal of DSBs is mediated by two major pathways: homologous recombination (HR) and nonhomologous endjoining (NHEJ). Capitalizing on existing genetic frameworks, biochemical reconstitution studies have begun to yield insights into the mechanistic underpinnings of these DNA repair reactions.

Original languageEnglish (US)
Title of host publicationProgress in Nucleic Acid Research and Molecular Biology
Pages159-201
Number of pages43
DOIs
StatePublished - Dec 1 2003

Publication series

NameProgress in Nucleic Acid Research and Molecular Biology
Volume74
ISSN (Print)0079-6603

ASJC Scopus subject areas

  • Molecular Biology

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