Men with family history of prostate cancer have a higher risk of disease recurrence after radical prostatectomy

Mark Thalgott, Martina Kron, Johannes M. Brath, Donna P Ankerst, Ian M. Thompson, Juergen E. Gschwend, Kathleen Herkommer

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Purpose: We aimed to determine if family history (FH) of prostate cancer (PC) influenced cancer control after radical prostatectomy (RP). Methods: Patients were evaluated in a prospectively-collected PC family database: The focus was on hereditary prostate cancer (HPC) defined by Johns Hopkins criteria and sporadic prostate cancer (SPC), rigorously defined by absence of prostate cancer in ≥ 2 brothers aged ≥ 60 years. Additionally, patients with first-degree (FPC) and non-first-degree PC (non-FPC) were assessed. Endpoints were biochemical recurrence-free survival (BRFS) and prostate cancer-specific survival (CSS). Finally, clinico-pathological characteristics were compared and multiple proportional hazards regression was used to identify prognostic factors. Results: In total 11,654 patients were included (807 HPC, 2251 FPC, 8072 non-FPC and 524 SPC). Familial imposition (HPC/FPC) was associated with a younger age at diagnosis. Thus, HPC patients were diagnosed 2.9 years earlier than SPC patients with more locally advanced tumors (≥ pT3). With a median follow up of 6.2 years (range 0–31.5) BRFS was significantly different when stratified by FH. In pairwise analyses BRFS differed significantly for HPC compared to SPC (HR = 1.27). Consecutively FH was identified as prognostic factor for BRFS (p = 0.021) together with age, PSA, pathologic characteristics and adjuvant androgen deprivation. Analyses of CSS did not show a difference. Conclusion: Patients with FH of PC are likely to be diagnosed earlier and present a higher proportion of locally advanced disease. In addition, men with FH are at higher risk of biochemical recurrence after surgery but reveal similar outcomes regarding prostate cancer-specific survival.

Original languageEnglish (US)
Pages (from-to)1-9
Number of pages9
JournalWorld Journal of Urology
DOIs
StateAccepted/In press - Nov 21 2017

    Fingerprint

Keywords

  • Family history
  • Hereditary prostate cancer
  • Radical prostatectomy
  • Sporadic prostate cancer

ASJC Scopus subject areas

  • Urology

Cite this

Thalgott, M., Kron, M., Brath, J. M., Ankerst, D. P., Thompson, I. M., Gschwend, J. E., & Herkommer, K. (Accepted/In press). Men with family history of prostate cancer have a higher risk of disease recurrence after radical prostatectomy. World Journal of Urology, 1-9. https://doi.org/10.1007/s00345-017-2122-5