Melatonin's role as an anticonvulsant and neuronal protector: Experimental and clinical evidence

Antonio Muñoz-Hoyos, Miguel Sánchez-Forte, Antonio Molina-Carballo, Germaine Escames, Encarnación Martin-Medina, Russel J Reiter, Juan A. Molina-Font, Darío Acuña-Castroviejo

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

The pineal gland classically has been considered as a vestigial and mystic organ. In the last decades, and with the incorporation of new methodologic procedures, it could be proved that it also has physiologic actions that vary depending on the level of the phylogenetic scale. Its best- known secretion, melatonin, has been related to many different actions, such as sleep promotion, control of biologic rhythms, hormonal inhibition, and an inhibiting action on central nervous system regulation mechanisms. In animal experimentation, there are papers even accepting an anticonvulsant effect. In humans, evidence is reduced to few experiences. In addition to this clinical experience, there is other evidence that clearly relates melatonin to convulsive phenomena. This relationship must be mediated by the following mechanisms attributed to melatonin: altered brain GABAergic neurotransmission, its known interaction with benzodiazepinic brain receptors, through tryptophan metabolite activity (kynurenine, kynurenic acid), or even by its efficacy as a free-radical scavenger.

Original languageEnglish (US)
Pages (from-to)501-509
Number of pages9
JournalJournal of Child Neurology
Volume13
Issue number10
StatePublished - Oct 1998

Fingerprint

Melatonin
Anticonvulsants
Kynurenic Acid
Kynurenine
Free Radical Scavengers
Pineal Gland
Brain
Synaptic Transmission
Tryptophan
Sleep
Central Nervous System

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health

Cite this

Muñoz-Hoyos, A., Sánchez-Forte, M., Molina-Carballo, A., Escames, G., Martin-Medina, E., Reiter, R. J., ... Acuña-Castroviejo, D. (1998). Melatonin's role as an anticonvulsant and neuronal protector: Experimental and clinical evidence. Journal of Child Neurology, 13(10), 501-509.

Melatonin's role as an anticonvulsant and neuronal protector : Experimental and clinical evidence. / Muñoz-Hoyos, Antonio; Sánchez-Forte, Miguel; Molina-Carballo, Antonio; Escames, Germaine; Martin-Medina, Encarnación; Reiter, Russel J; Molina-Font, Juan A.; Acuña-Castroviejo, Darío.

In: Journal of Child Neurology, Vol. 13, No. 10, 10.1998, p. 501-509.

Research output: Contribution to journalArticle

Muñoz-Hoyos, A, Sánchez-Forte, M, Molina-Carballo, A, Escames, G, Martin-Medina, E, Reiter, RJ, Molina-Font, JA & Acuña-Castroviejo, D 1998, 'Melatonin's role as an anticonvulsant and neuronal protector: Experimental and clinical evidence', Journal of Child Neurology, vol. 13, no. 10, pp. 501-509.
Muñoz-Hoyos A, Sánchez-Forte M, Molina-Carballo A, Escames G, Martin-Medina E, Reiter RJ et al. Melatonin's role as an anticonvulsant and neuronal protector: Experimental and clinical evidence. Journal of Child Neurology. 1998 Oct;13(10):501-509.
Muñoz-Hoyos, Antonio ; Sánchez-Forte, Miguel ; Molina-Carballo, Antonio ; Escames, Germaine ; Martin-Medina, Encarnación ; Reiter, Russel J ; Molina-Font, Juan A. ; Acuña-Castroviejo, Darío. / Melatonin's role as an anticonvulsant and neuronal protector : Experimental and clinical evidence. In: Journal of Child Neurology. 1998 ; Vol. 13, No. 10. pp. 501-509.
@article{5de286d7610d448083d90dd87240e143,
title = "Melatonin's role as an anticonvulsant and neuronal protector: Experimental and clinical evidence",
abstract = "The pineal gland classically has been considered as a vestigial and mystic organ. In the last decades, and with the incorporation of new methodologic procedures, it could be proved that it also has physiologic actions that vary depending on the level of the phylogenetic scale. Its best- known secretion, melatonin, has been related to many different actions, such as sleep promotion, control of biologic rhythms, hormonal inhibition, and an inhibiting action on central nervous system regulation mechanisms. In animal experimentation, there are papers even accepting an anticonvulsant effect. In humans, evidence is reduced to few experiences. In addition to this clinical experience, there is other evidence that clearly relates melatonin to convulsive phenomena. This relationship must be mediated by the following mechanisms attributed to melatonin: altered brain GABAergic neurotransmission, its known interaction with benzodiazepinic brain receptors, through tryptophan metabolite activity (kynurenine, kynurenic acid), or even by its efficacy as a free-radical scavenger.",
author = "Antonio Mu{\~n}oz-Hoyos and Miguel S{\'a}nchez-Forte and Antonio Molina-Carballo and Germaine Escames and Encarnaci{\'o}n Martin-Medina and Reiter, {Russel J} and Molina-Font, {Juan A.} and Dar{\'i}o Acu{\~n}a-Castroviejo",
year = "1998",
month = "10",
language = "English (US)",
volume = "13",
pages = "501--509",
journal = "Journal of Child Neurology",
issn = "0883-0738",
publisher = "SAGE Publications Inc.",
number = "10",

}

TY - JOUR

T1 - Melatonin's role as an anticonvulsant and neuronal protector

T2 - Experimental and clinical evidence

AU - Muñoz-Hoyos, Antonio

AU - Sánchez-Forte, Miguel

AU - Molina-Carballo, Antonio

AU - Escames, Germaine

AU - Martin-Medina, Encarnación

AU - Reiter, Russel J

AU - Molina-Font, Juan A.

AU - Acuña-Castroviejo, Darío

PY - 1998/10

Y1 - 1998/10

N2 - The pineal gland classically has been considered as a vestigial and mystic organ. In the last decades, and with the incorporation of new methodologic procedures, it could be proved that it also has physiologic actions that vary depending on the level of the phylogenetic scale. Its best- known secretion, melatonin, has been related to many different actions, such as sleep promotion, control of biologic rhythms, hormonal inhibition, and an inhibiting action on central nervous system regulation mechanisms. In animal experimentation, there are papers even accepting an anticonvulsant effect. In humans, evidence is reduced to few experiences. In addition to this clinical experience, there is other evidence that clearly relates melatonin to convulsive phenomena. This relationship must be mediated by the following mechanisms attributed to melatonin: altered brain GABAergic neurotransmission, its known interaction with benzodiazepinic brain receptors, through tryptophan metabolite activity (kynurenine, kynurenic acid), or even by its efficacy as a free-radical scavenger.

AB - The pineal gland classically has been considered as a vestigial and mystic organ. In the last decades, and with the incorporation of new methodologic procedures, it could be proved that it also has physiologic actions that vary depending on the level of the phylogenetic scale. Its best- known secretion, melatonin, has been related to many different actions, such as sleep promotion, control of biologic rhythms, hormonal inhibition, and an inhibiting action on central nervous system regulation mechanisms. In animal experimentation, there are papers even accepting an anticonvulsant effect. In humans, evidence is reduced to few experiences. In addition to this clinical experience, there is other evidence that clearly relates melatonin to convulsive phenomena. This relationship must be mediated by the following mechanisms attributed to melatonin: altered brain GABAergic neurotransmission, its known interaction with benzodiazepinic brain receptors, through tryptophan metabolite activity (kynurenine, kynurenic acid), or even by its efficacy as a free-radical scavenger.

UR - http://www.scopus.com/inward/record.url?scp=0031729787&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031729787&partnerID=8YFLogxK

M3 - Article

C2 - 9796757

AN - SCOPUS:0031729787

VL - 13

SP - 501

EP - 509

JO - Journal of Child Neurology

JF - Journal of Child Neurology

SN - 0883-0738

IS - 10

ER -