Melatonin: The smart killer. The human trophoblast as a model

Dave Lanoix, Andrée Anne Lacasse, Russel J. Reiter, Cathy Vaillancourt

Research output: Contribution to journalReview article

64 Scopus citations

Abstract

Melatonin has both the ability to induce intrinsic apoptosis in tumor cells while it inhibits it in non-tumor cells. Melatonin kills tumor cells through induction of reactive oxygen species generation and activation of pro-apoptotic pathways. In contrast, melatonin promotes the survival of non-tumor cells due to its antioxidant properties and the inhibition of pro-apoptotic pathways. In primary human villous trophoblast, a known pseudo-tumorigenic tissue, melatonin promotes the survival through inhibition of the Bax/Bcl-2 pathway while in BeWo choriocarcinoma cell line melatonin induces permeabilization of the mitochondrial membrane leading to cellular death. These findings suggest that the trophoblast is a good model to study the differential effects of melatonin on the intrinsic apoptosis pathway. This review describes the differential effects of melatonin on the intrinsic apoptosis pathway in tumor and non-tumor cells and presents the trophoblast as a novel model system in which to study these effects of melatonin.

Original languageEnglish (US)
Pages (from-to)1-11
Number of pages11
JournalMolecular and Cellular Endocrinology
Volume348
Issue number1
DOIs
StatePublished - Jan 2 2012

Keywords

  • Extrinsic apoptosis
  • Intrinsic apoptosis
  • Non-tumor cells
  • Placenta
  • Tumor cells

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Endocrinology

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