Melatonin stimulation of prolactin secretion in male rats: Influence of pinealectomy, castration or gonadal steroid pretreatment

M. K. Vaughan; L. Y. Johnson; D. E. Blask; R. J. Reiter

doi:10.1016/b978-0-08-026400-4.50025-6

Melatonin stimulation of prolactin secretion in male rats: Influence of pinealectomy, castration or gonadal steroid pretreatment

M. K. Vaughan, L. Y. Johnson, D. E. Blask, R. J. Reiter

Cell Systems & Anatomy

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Intravenous administration of melatonin stimulates plasma prolactin (PRL) secretion in untreated or estrogen-progesterone, urethane-anesthetized adult male rats. Melatonin failed to elicit the plasma PRL response either in rats which had been previously primed for 3 days with either estrogen or progesterone alone or in castrated rats. Replacement treatment with sc injections of testosterone propionate in castrated rats restored the PRL response to melatonin injections. Since PRL levels in pinealectomized rats rose after administration of melatonin, it is thought that the PRL-releasing effect of the indole is not immediately and directly via an action of melatonin on the pineal.

Original language	English (US)
Pages (from-to)	165-170
Number of pages	6
Journal	Advances in the Biosciences
Volume	29
Issue number	C
DOIs	https://doi.org/10.1016/b978-0-08-026400-4.50025-6
State	Published - 1981

Keywords

Melatonin
castration
pineal
pinealectomy
prolactin

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10.1016/b978-0-08-026400-4.50025-6

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title = "Melatonin stimulation of prolactin secretion in male rats: Influence of pinealectomy, castration or gonadal steroid pretreatment",

abstract = "Intravenous administration of melatonin stimulates plasma prolactin (PRL) secretion in untreated or estrogen-progesterone, urethane-anesthetized adult male rats. Melatonin failed to elicit the plasma PRL response either in rats which had been previously primed for 3 days with either estrogen or progesterone alone or in castrated rats. Replacement treatment with sc injections of testosterone propionate in castrated rats restored the PRL response to melatonin injections. Since PRL levels in pinealectomized rats rose after administration of melatonin, it is thought that the PRL-releasing effect of the indole is not immediately and directly via an action of melatonin on the pineal.",

keywords = "Melatonin, castration, pineal, pinealectomy, prolactin",

author = "Vaughan, {M. K.} and Johnson, {L. Y.} and Blask, {D. E.} and Reiter, {R. J.}",

note = "Funding Information: Supported by NSF grant PCM 800-3441 and NIH Center for Reproductive Biology P 30 HD10202. Thanks are due A. Moreno (Bioassay Core) for excellent technical assistance. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",

year = "1981",

doi = "10.1016/b978-0-08-026400-4.50025-6",

language = "English (US)",

volume = "29",

pages = "165--170",

journal = "Advances in the Biosciences",

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T2 - Influence of pinealectomy, castration or gonadal steroid pretreatment

AU - Vaughan, M. K.

AU - Johnson, L. Y.

AU - Blask, D. E.

AU - Reiter, R. J.

N1 - Funding Information: Supported by NSF grant PCM 800-3441 and NIH Center for Reproductive Biology P 30 HD10202. Thanks are due A. Moreno (Bioassay Core) for excellent technical assistance. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 1981

Y1 - 1981

N2 - Intravenous administration of melatonin stimulates plasma prolactin (PRL) secretion in untreated or estrogen-progesterone, urethane-anesthetized adult male rats. Melatonin failed to elicit the plasma PRL response either in rats which had been previously primed for 3 days with either estrogen or progesterone alone or in castrated rats. Replacement treatment with sc injections of testosterone propionate in castrated rats restored the PRL response to melatonin injections. Since PRL levels in pinealectomized rats rose after administration of melatonin, it is thought that the PRL-releasing effect of the indole is not immediately and directly via an action of melatonin on the pineal.

AB - Intravenous administration of melatonin stimulates plasma prolactin (PRL) secretion in untreated or estrogen-progesterone, urethane-anesthetized adult male rats. Melatonin failed to elicit the plasma PRL response either in rats which had been previously primed for 3 days with either estrogen or progesterone alone or in castrated rats. Replacement treatment with sc injections of testosterone propionate in castrated rats restored the PRL response to melatonin injections. Since PRL levels in pinealectomized rats rose after administration of melatonin, it is thought that the PRL-releasing effect of the indole is not immediately and directly via an action of melatonin on the pineal.

KW - Melatonin

KW - castration

KW - pineal

KW - pinealectomy

KW - prolactin

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Melatonin stimulation of prolactin secretion in male rats: Influence of pinealectomy, castration or gonadal steroid pretreatment

Abstract

Keywords

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