Melatonin specifically stimulates type-II thyroxine 5'-deiodination in brown adipose tissue of Syrian hamsters

M. Puig-Domingo, J. M. Guerrero, A. Menendez-Pelaez, Russel J Reiter

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The resposne of type-II thyroxine 5'-deiodinase (5'-DII) to melatonin treatment was studied in the Syrian hamster. Male hamsters were treated for 15 days with a s.c. pellet containing melatonin, and 5'-DII activity in brown adipose tissue, anterior pituitary gland, Harderian gland and pineal gland was measured using a radioenzymatic technique. Melatonin-treated animals exhibited enhanced 5'-DII activity restricted to brown adipose tissue; the increase was threefold above the values measured in the control group. Serum concentrations of thyroid hormones were unaffected by melatonin treatment. We conclude that the stimulatory effect of melatonin on type-II thyroxine 5'-deiodination is specifically directed to the isoenzyme located in brown adipose tissue and is not accompanied by changes in serum thyroid hormones.

Original languageEnglish (US)
Pages (from-to)553-556
Number of pages4
JournalJournal of Endocrinology
Volume122
Issue number2
StatePublished - 1989

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Brown Adipose Tissue
Mesocricetus
Melatonin
Thyroxine
Iodide Peroxidase
Thyroid Hormones
Harderian Gland
Anterior Pituitary Gland
Pineal Gland
Serum
Cricetinae
Isoenzymes
Control Groups

ASJC Scopus subject areas

  • Endocrinology

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Melatonin specifically stimulates type-II thyroxine 5'-deiodination in brown adipose tissue of Syrian hamsters. / Puig-Domingo, M.; Guerrero, J. M.; Menendez-Pelaez, A.; Reiter, Russel J.

In: Journal of Endocrinology, Vol. 122, No. 2, 1989, p. 553-556.

Research output: Contribution to journalArticle

Puig-Domingo, M. ; Guerrero, J. M. ; Menendez-Pelaez, A. ; Reiter, Russel J. / Melatonin specifically stimulates type-II thyroxine 5'-deiodination in brown adipose tissue of Syrian hamsters. In: Journal of Endocrinology. 1989 ; Vol. 122, No. 2. pp. 553-556.
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