Melatonin signaling in T cells

Functions and applications

Wenkai Ren, Gang Liu, Shuai Chen, Jie Yin, Jing Wang, Bie Tan, Guoyao Wu, Fuller W. Bazer, Yuanyi Peng, Tiejun Li, Russel J Reiter, Yulong Yin

Research output: Contribution to journalReview article

58 Citations (Scopus)

Abstract

Melatonin affects a variety of physiological processes including circadian rhythms, cellular redox status, and immune function. Importantly, melatonin significantly influences T-cell-mediated immune responses, which are crucial to protect mammals against cancers and infections, but are associated with pathogenesis of many autoimmune diseases. This review focuses on our current understanding of the significance of melatonin in T-cell biology and the beneficial effects of melatonin in T-cell response-based diseases. In addition to expressing both membrane and nuclear receptors for melatonin, T cells have the four enzymes required for the synthesis of melatonin and produce high levels of melatonin. Meanwhile, melatonin is highly effective in modulating T-cell activation and differentiation, especially for Th17 and Treg cells, and also memory T cells. Mechanistically, the influence of melatonin in T-cell biology is associated with membrane and nuclear receptors as well as receptor-independent pathways, for example, via calcineurin. Several cell signaling pathways, including ERK1/2-C/EBPα, are involved in the regulatory roles of melatonin in T-cell biology. Through modulation in T-cell responses, melatonin exerts beneficial effects in various inflammatory diseases, such as type 1 diabetes, systemic lupus erythematosus, and multiple sclerosis. These findings highlight the importance of melatonin signaling in T-cell fate determination, and T cell-based immune pathologies.

Original languageEnglish (US)
Article numbere12394
JournalJournal of Pineal Research
Volume62
Issue number3
DOIs
StatePublished - Apr 1 2017

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Melatonin
T-Lymphocytes
Cell Biology
Cytoplasmic and Nuclear Receptors
Physiological Phenomena
Th17 Cells
Membranes
MAP Kinase Signaling System
Calcineurin
Regulatory T-Lymphocytes
Circadian Rhythm
Type 1 Diabetes Mellitus
Systemic Lupus Erythematosus
Autoimmune Diseases
Multiple Sclerosis
Oxidation-Reduction
Cell Differentiation
Mammals
Pathology

Keywords

  • melatonin
  • multiple sclerosis
  • systemic lupus erythematosus
  • T cells
  • Th17 cells
  • Treg cells

ASJC Scopus subject areas

  • Endocrinology

Cite this

Ren, W., Liu, G., Chen, S., Yin, J., Wang, J., Tan, B., ... Yin, Y. (2017). Melatonin signaling in T cells: Functions and applications. Journal of Pineal Research, 62(3), [e12394]. https://doi.org/10.1111/jpi.12394

Melatonin signaling in T cells : Functions and applications. / Ren, Wenkai; Liu, Gang; Chen, Shuai; Yin, Jie; Wang, Jing; Tan, Bie; Wu, Guoyao; Bazer, Fuller W.; Peng, Yuanyi; Li, Tiejun; Reiter, Russel J; Yin, Yulong.

In: Journal of Pineal Research, Vol. 62, No. 3, e12394, 01.04.2017.

Research output: Contribution to journalReview article

Ren, W, Liu, G, Chen, S, Yin, J, Wang, J, Tan, B, Wu, G, Bazer, FW, Peng, Y, Li, T, Reiter, RJ & Yin, Y 2017, 'Melatonin signaling in T cells: Functions and applications', Journal of Pineal Research, vol. 62, no. 3, e12394. https://doi.org/10.1111/jpi.12394
Ren W, Liu G, Chen S, Yin J, Wang J, Tan B et al. Melatonin signaling in T cells: Functions and applications. Journal of Pineal Research. 2017 Apr 1;62(3). e12394. https://doi.org/10.1111/jpi.12394
Ren, Wenkai ; Liu, Gang ; Chen, Shuai ; Yin, Jie ; Wang, Jing ; Tan, Bie ; Wu, Guoyao ; Bazer, Fuller W. ; Peng, Yuanyi ; Li, Tiejun ; Reiter, Russel J ; Yin, Yulong. / Melatonin signaling in T cells : Functions and applications. In: Journal of Pineal Research. 2017 ; Vol. 62, No. 3.
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