Melatonin secretion and metabolism in patients with hepatic encephalopathy

Cezary Chojnacki, Patrycja Wachowska-Kelly, Janusz Błasiak, Russel J. Reiter, Jan Chojnacki

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Background and Aim: The rhythm of melatonin secretion and its blood level changes in cirrhotic patients, but the causes of these alterations have not been sufficiently appreciated. The aim of study was to estimate the dependence between melatonin secretion and metabolism and the severity of hepatic encephalopathy. Methods: The study included 75 alcoholic cirrhotic patients (A, B, C) with hepatic insufficiency and 25 healthy subjects (group K). Three groups of patients were identified, 25 patients each, with grade 1, 2, and 3 hepatic encephalopathy according to West-Haven Scale. Immunoenzymatic method was used to measure serum melatonin (at 02:00h and 09:00h) level and 6-sulfatoxymelatonin (6-HMS) excretion in the urine (during night and day). Results: Nocturnal serum melatonin levels (pg/mL) in groups were: K-57.1±11.4, A-38.5±11.2, B-53.4±17.9, C-79.5±27.9 (P<0.01); whereas diurnal levels were: K-10.9±3.5, A-33.5±12.0, B-53.8±23.1, C-98.5±34.6 (P<0.01). Similar differences were found in the evaluation of 6-HMS excretion (μg/9h) in urine at night: group K-23.4±14.4, A-16.6±5.4, B-14.3±6.2 (P<0.01), C-3.3±1.5 (P<0.001). Diurnal 6-HMS excretion (μg/15h) was lower only in group C and it was respectively: K-6.9±3.4, A-7.1±1.7, B-7.6±1.7, C-4.3±2.2 (P<0.001). Serum ammonia concentrations (μg/dL) were: group K-30.4±8.9, A-51.8±25.4 (P<0.05), B-73.0±29.8 (P<0.001), C-107.5±34.8 (P<0.001). No correlation between melatonin and ammonia levels in all groups was found. Conclusions: The elevated melatonin blood levels both at night and day may account for some of the clinical manifestations of hepatic encephalopathy (daytime sleepiness, fatigue).

Original languageEnglish (US)
Pages (from-to)342-347
Number of pages6
JournalJournal of Gastroenterology and Hepatology (Australia)
Issue number2
StatePublished - Feb 2013
Externally publishedYes


  • 6-sulfatoxymelatonin
  • Hepatic encephalopathy
  • Liver cirrhosis
  • Melatonin

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology


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