Melatonin role preventing steatohepatitis and improving liver transplantation results

Eduardo Esteban-Zubero, Francisco Agustín García-Gil, Laura López-Pingarrón, Moisés Alejandro Alatorre-Jiménez, José Manuel Ramírez, Dun Xian Tan, José Joaquín García, Russel J Reiter

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Liver steatosis is a prevalent process that is induced due to alcoholic or non-alcoholic intake. During the course of these diseases, the generation of reactive oxygen species, followed by molecular damage to lipids, protein and DMA occurs generating organ cell death. Transplantation is the last-resort treatment for the end stage of both acute and chronic hepatic diseases, but its success depends on ability to control ischemia–reperfusion injury, preservation fluids used, and graft quality. Melatonin is a powerful endogenous antioxidant produced by the pineal gland and a variety of other because of its efficacy in organs; melatonin has been investigated to improve the outcome of organ transplantation by reducing ischemia–reperfusion injury and due to its synergic effect with organ preservation fluids. Moreover, this indolamine also prevent liver steatosis. That is important because this disease may evolve leading to an organ transplantation. This review summarizes the observations related to melatonin beneficial actions in organ transplantation and ischemic–reperfusion models.

Original languageEnglish (US)
Pages (from-to)1-17
Number of pages17
JournalCellular and Molecular Life Sciences
DOIs
StateAccepted/In press - Mar 29 2016

Keywords

  • Alcohol
  • Ischemia–reperfusion injury
  • Liver transplantation
  • Melatonin
  • Preservation fluids
  • Steatosis

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Molecular Medicine
  • Pharmacology
  • Cellular and Molecular Neuroscience

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  • Cite this

    Esteban-Zubero, E., García-Gil, F. A., López-Pingarrón, L., Alatorre-Jiménez, M. A., Ramírez, J. M., Tan, D. X., García, J. J., & Reiter, R. J. (Accepted/In press). Melatonin role preventing steatohepatitis and improving liver transplantation results. Cellular and Molecular Life Sciences, 1-17. https://doi.org/10.1007/s00018-016-2185-2