Abstract
Liver steatosis is a prevalent process that is induced due to alcoholic or non-alcoholic intake. During the course of these diseases, the generation of reactive oxygen species, followed by molecular damage to lipids, protein and DMA occurs generating organ cell death. Transplantation is the last-resort treatment for the end stage of both acute and chronic hepatic diseases, but its success depends on ability to control ischemia–reperfusion injury, preservation fluids used, and graft quality. Melatonin is a powerful endogenous antioxidant produced by the pineal gland and a variety of other because of its efficacy in organs; melatonin has been investigated to improve the outcome of organ transplantation by reducing ischemia–reperfusion injury and due to its synergic effect with organ preservation fluids. Moreover, this indolamine also prevent liver steatosis. That is important because this disease may evolve leading to an organ transplantation. This review summarizes the observations related to melatonin beneficial actions in organ transplantation and ischemic–reperfusion models.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1-17 |
| Number of pages | 17 |
| Journal | Cellular and Molecular Life Sciences |
| DOIs | |
| State | Accepted/In press - Mar 29 2016 |
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Keywords
- Alcohol
- Ischemia–reperfusion injury
- Liver transplantation
- Melatonin
- Preservation fluids
- Steatosis
ASJC Scopus subject areas
- Cell Biology
- Molecular Biology
- Molecular Medicine
- Pharmacology
- Cellular and Molecular Neuroscience
Cite this
Melatonin role preventing steatohepatitis and improving liver transplantation results. / Esteban-Zubero, Eduardo; García-Gil, Francisco Agustín; López-Pingarrón, Laura; Alatorre-Jiménez, Moisés Alejandro; Ramírez, José Manuel; Tan, Dun Xian; García, José Joaquín; Reiter, Russel J.
In: Cellular and Molecular Life Sciences, 29.03.2016, p. 1-17.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Melatonin role preventing steatohepatitis and improving liver transplantation results
AU - Esteban-Zubero, Eduardo
AU - García-Gil, Francisco Agustín
AU - López-Pingarrón, Laura
AU - Alatorre-Jiménez, Moisés Alejandro
AU - Ramírez, José Manuel
AU - Tan, Dun Xian
AU - García, José Joaquín
AU - Reiter, Russel J
PY - 2016/3/29
Y1 - 2016/3/29
N2 - Liver steatosis is a prevalent process that is induced due to alcoholic or non-alcoholic intake. During the course of these diseases, the generation of reactive oxygen species, followed by molecular damage to lipids, protein and DMA occurs generating organ cell death. Transplantation is the last-resort treatment for the end stage of both acute and chronic hepatic diseases, but its success depends on ability to control ischemia–reperfusion injury, preservation fluids used, and graft quality. Melatonin is a powerful endogenous antioxidant produced by the pineal gland and a variety of other because of its efficacy in organs; melatonin has been investigated to improve the outcome of organ transplantation by reducing ischemia–reperfusion injury and due to its synergic effect with organ preservation fluids. Moreover, this indolamine also prevent liver steatosis. That is important because this disease may evolve leading to an organ transplantation. This review summarizes the observations related to melatonin beneficial actions in organ transplantation and ischemic–reperfusion models.
AB - Liver steatosis is a prevalent process that is induced due to alcoholic or non-alcoholic intake. During the course of these diseases, the generation of reactive oxygen species, followed by molecular damage to lipids, protein and DMA occurs generating organ cell death. Transplantation is the last-resort treatment for the end stage of both acute and chronic hepatic diseases, but its success depends on ability to control ischemia–reperfusion injury, preservation fluids used, and graft quality. Melatonin is a powerful endogenous antioxidant produced by the pineal gland and a variety of other because of its efficacy in organs; melatonin has been investigated to improve the outcome of organ transplantation by reducing ischemia–reperfusion injury and due to its synergic effect with organ preservation fluids. Moreover, this indolamine also prevent liver steatosis. That is important because this disease may evolve leading to an organ transplantation. This review summarizes the observations related to melatonin beneficial actions in organ transplantation and ischemic–reperfusion models.
KW - Alcohol
KW - Ischemia–reperfusion injury
KW - Liver transplantation
KW - Melatonin
KW - Preservation fluids
KW - Steatosis
UR - http://www.scopus.com/inward/record.url?scp=84962298587&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84962298587&partnerID=8YFLogxK
U2 - 10.1007/s00018-016-2185-2
DO - 10.1007/s00018-016-2185-2
M3 - Article
C2 - 27022943
AN - SCOPUS:84962298587
SP - 1
EP - 17
JO - Cellular and Molecular Life Sciences
JF - Cellular and Molecular Life Sciences
SN - 1420-682X
ER -