TY - JOUR
T1 - Melatonin reprogramming of gut microbiota improves lipid dysmetabolism in high-fat diet-fed mice
AU - Yin, Jie
AU - Li, Yuying
AU - Han, Hui
AU - Chen, Shuai
AU - Gao, Jing
AU - Liu, Gang
AU - Wu, Xin
AU - Deng, Jinping
AU - Yu, Qifang
AU - Huang, Xingguo
AU - Fang, Rejun
AU - Li, Tiejun
AU - Reiter, Russel J.
AU - Zhang, Dong
AU - Zhu, Congrui
AU - Zhu, Guoqiang
AU - Ren, Wenkai
AU - Yin, Yulong
N1 - Funding Information:
This study was supported by the National Key Research and Development Program of China (2016YFD0501200 and 2016YFD0500500), National Natural Science Foundation of China (31472106, 31772617, 31872365 and 31790411), Key Programs of frontier scientific research of the Chinese Academy of Sciences (QYZDY‐SSW‐SMC008), Hunan Key Research Program (2017NK2320).
Funding Information:
National Key Research and Development Program, Grant/Award Numbers: 2016YFD0501200 and 2016YFD0500500; National Natural Science Foundation of China, Grant/Award Numbers: 31472106, 31772617, 31872365 and 31790411; Chinese Academy of Sciences, Grant/Award Number: QYZDY-SSWSMC008; Hunan Key Research Program, Grant/Award Number: 2017NK2320
Publisher Copyright:
© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
PY - 2018/11
Y1 - 2018/11
N2 - Melatonin has been shown to improve lipid metabolism and gut microbiota communities in animals and humans; however, it remains to know whether melatonin prevents obesity through gut microbiota. Here, we found that high-fat diet promoted the lipid accumulation and intestinal microbiota dysbiosis in mice, while oral melatonin supplementation alleviated the lipid accumulation and reversed gut microbiota dysbiosis, including the diversity of intestinal microbiota, relative abundances of Bacteroides and Alistipes, and functional profiling of microbial communities, such as energy metabolism, lipid metabolism, and carbohydrate metabolism. Interestingly, melatonin failed to alleviate the high-fat-induced lipid accumulation in antibiotic-treated mice; however, microbiota transplantation from melatonin-treated mice alleviated high-fat diet-induced lipid metabolic disorders. Notably, short-chain fatty acids were decreased in high-fat diet-fed mice, while melatonin treatment improved the production of acetic acid. Correlation analysis found a marked correlation between production of acetic acid and relative abundances of Bacteroides and Alistipes. Importantly, sodium acetate treatment also alleviated high-fat diet-induced lipid metabolic disorders. Taken together, our results suggest that melatonin improves lipid metabolism in high-fat diet-fed mice, and the potential mechanisms may be associated with reprogramming gut microbiota, especially, Bacteroides and Alistipes-mediated acetic acid production. Future studies are needed for patients with metabolic syndrome to fully understand melatonin’s effects on body weight and lipid profiles and the potential mechanism of gut microbiota.
AB - Melatonin has been shown to improve lipid metabolism and gut microbiota communities in animals and humans; however, it remains to know whether melatonin prevents obesity through gut microbiota. Here, we found that high-fat diet promoted the lipid accumulation and intestinal microbiota dysbiosis in mice, while oral melatonin supplementation alleviated the lipid accumulation and reversed gut microbiota dysbiosis, including the diversity of intestinal microbiota, relative abundances of Bacteroides and Alistipes, and functional profiling of microbial communities, such as energy metabolism, lipid metabolism, and carbohydrate metabolism. Interestingly, melatonin failed to alleviate the high-fat-induced lipid accumulation in antibiotic-treated mice; however, microbiota transplantation from melatonin-treated mice alleviated high-fat diet-induced lipid metabolic disorders. Notably, short-chain fatty acids were decreased in high-fat diet-fed mice, while melatonin treatment improved the production of acetic acid. Correlation analysis found a marked correlation between production of acetic acid and relative abundances of Bacteroides and Alistipes. Importantly, sodium acetate treatment also alleviated high-fat diet-induced lipid metabolic disorders. Taken together, our results suggest that melatonin improves lipid metabolism in high-fat diet-fed mice, and the potential mechanisms may be associated with reprogramming gut microbiota, especially, Bacteroides and Alistipes-mediated acetic acid production. Future studies are needed for patients with metabolic syndrome to fully understand melatonin’s effects on body weight and lipid profiles and the potential mechanism of gut microbiota.
KW - acetic acid
KW - gut microbiota
KW - lipid metabolism
KW - melatonin
KW - microbiota transplantation
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U2 - 10.1111/jpi.12524
DO - 10.1111/jpi.12524
M3 - Article
C2 - 30230594
AN - SCOPUS:85054922052
SN - 0742-3098
VL - 65
JO - Journal of pineal research
JF - Journal of pineal research
IS - 4
M1 - e12524
ER -