Melatonin: reproductive effects.

Russel J Reiter, M. D. Rollag, E. S. Panke, A. F. Banks

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

N-acetyl-5-methoxytryptamine, melatonin, is synthesized within and secreted from the pineal gland. Although the concentration of this constituent in the blood is diminished after surgical removal of the pineal gland it does not completely disappear. Other potential contributors to blood titers of melatonin include the retinas, the Harderian glands and the gastro-intestinal tract. Melatonin has a potent antigonadotrophic action in the Syrian hamster ( a highly photosensitive species) provided the indole is given during a restricted portion of the light phase of the light-dark cycle. This so-called sensitive period falls late in the light phase; melatonin acutely administered at other times has virtually no inhibitory influence on the reproductive physiology of hamsters. When melatonin is continuously available (from a subcutaneous deposit) it counteracts the antigonadotrophic influence of the pineal gland in light restricted or blinded hamsters, i.e., it causes a "functional pinealectomy". Furthermore, chronically available melatonin negates the antigonadotrophic capability of acute melatonin injections.

Original languageEnglish (US)
Pages (from-to)209-223
Number of pages15
JournalJournal of Neural Transmission, Supplement
Issue number13
StatePublished - 1978
Externally publishedYes

Fingerprint

Melatonin
Pineal Gland
Light
Cricetinae
Harderian Gland
5-Methoxytryptamine
Mesocricetus
Photoperiod
Retina
Injections

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Reiter, R. J., Rollag, M. D., Panke, E. S., & Banks, A. F. (1978). Melatonin: reproductive effects. Journal of Neural Transmission, Supplement, (13), 209-223.

Melatonin : reproductive effects. / Reiter, Russel J; Rollag, M. D.; Panke, E. S.; Banks, A. F.

In: Journal of Neural Transmission, Supplement, No. 13, 1978, p. 209-223.

Research output: Contribution to journalArticle

Reiter, RJ, Rollag, MD, Panke, ES & Banks, AF 1978, 'Melatonin: reproductive effects.', Journal of Neural Transmission, Supplement, no. 13, pp. 209-223.
Reiter, Russel J ; Rollag, M. D. ; Panke, E. S. ; Banks, A. F. / Melatonin : reproductive effects. In: Journal of Neural Transmission, Supplement. 1978 ; No. 13. pp. 209-223.
@article{85905608a4024e12bb28ecbc3650d549,
title = "Melatonin: reproductive effects.",
abstract = "N-acetyl-5-methoxytryptamine, melatonin, is synthesized within and secreted from the pineal gland. Although the concentration of this constituent in the blood is diminished after surgical removal of the pineal gland it does not completely disappear. Other potential contributors to blood titers of melatonin include the retinas, the Harderian glands and the gastro-intestinal tract. Melatonin has a potent antigonadotrophic action in the Syrian hamster ( a highly photosensitive species) provided the indole is given during a restricted portion of the light phase of the light-dark cycle. This so-called sensitive period falls late in the light phase; melatonin acutely administered at other times has virtually no inhibitory influence on the reproductive physiology of hamsters. When melatonin is continuously available (from a subcutaneous deposit) it counteracts the antigonadotrophic influence of the pineal gland in light restricted or blinded hamsters, i.e., it causes a {"}functional pinealectomy{"}. Furthermore, chronically available melatonin negates the antigonadotrophic capability of acute melatonin injections.",
author = "Reiter, {Russel J} and Rollag, {M. D.} and Panke, {E. S.} and Banks, {A. F.}",
year = "1978",
language = "English (US)",
pages = "209--223",
journal = "Journal of neural transmission. Supplementum",
issn = "0303-6995",
publisher = "Springer Wien",
number = "13",

}

TY - JOUR

T1 - Melatonin

T2 - reproductive effects.

AU - Reiter, Russel J

AU - Rollag, M. D.

AU - Panke, E. S.

AU - Banks, A. F.

PY - 1978

Y1 - 1978

N2 - N-acetyl-5-methoxytryptamine, melatonin, is synthesized within and secreted from the pineal gland. Although the concentration of this constituent in the blood is diminished after surgical removal of the pineal gland it does not completely disappear. Other potential contributors to blood titers of melatonin include the retinas, the Harderian glands and the gastro-intestinal tract. Melatonin has a potent antigonadotrophic action in the Syrian hamster ( a highly photosensitive species) provided the indole is given during a restricted portion of the light phase of the light-dark cycle. This so-called sensitive period falls late in the light phase; melatonin acutely administered at other times has virtually no inhibitory influence on the reproductive physiology of hamsters. When melatonin is continuously available (from a subcutaneous deposit) it counteracts the antigonadotrophic influence of the pineal gland in light restricted or blinded hamsters, i.e., it causes a "functional pinealectomy". Furthermore, chronically available melatonin negates the antigonadotrophic capability of acute melatonin injections.

AB - N-acetyl-5-methoxytryptamine, melatonin, is synthesized within and secreted from the pineal gland. Although the concentration of this constituent in the blood is diminished after surgical removal of the pineal gland it does not completely disappear. Other potential contributors to blood titers of melatonin include the retinas, the Harderian glands and the gastro-intestinal tract. Melatonin has a potent antigonadotrophic action in the Syrian hamster ( a highly photosensitive species) provided the indole is given during a restricted portion of the light phase of the light-dark cycle. This so-called sensitive period falls late in the light phase; melatonin acutely administered at other times has virtually no inhibitory influence on the reproductive physiology of hamsters. When melatonin is continuously available (from a subcutaneous deposit) it counteracts the antigonadotrophic influence of the pineal gland in light restricted or blinded hamsters, i.e., it causes a "functional pinealectomy". Furthermore, chronically available melatonin negates the antigonadotrophic capability of acute melatonin injections.

UR - http://www.scopus.com/inward/record.url?scp=0018229744&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018229744&partnerID=8YFLogxK

M3 - Article

C2 - 381586

AN - SCOPUS:0018229744

SP - 209

EP - 223

JO - Journal of neural transmission. Supplementum

JF - Journal of neural transmission. Supplementum

SN - 0303-6995

IS - 13

ER -