TY - JOUR
T1 - Melatonin-Related Hypogonadotropic Hypogonadism
AU - Puig-Domingo, Manuel
AU - Webb, Susan M.
AU - Serrano, José
AU - Peinado, Miguel Angel
AU - Corcoy, Rosa
AU - Ruscalleda, Jordi
AU - Reiter, Russel J.
AU - de Leiva, Alberto
PY - 1992/11/5
Y1 - 1992/11/5
N2 - THE secretion of melatonin from the pineal gland is linked to the light–dark cycle, being greater at night in all species, including humans, and it is pulsatile.1 In humans the peak nocturnal plasma melatonin concentration declines progressively with age, being highest in infants and prepubertal children and lowest in elderly people. Melatonin profoundly influences reproductive function in seasonally breeding mammals. One such species is the Syrian hamster, in which pinealectomy leads to sustained reproductive activity and in which appropriately timed injections of melatonin inhibit reproductive function.2 It is less clear whether melatonin has regulatory actions on the reproductive system in…
AB - THE secretion of melatonin from the pineal gland is linked to the light–dark cycle, being greater at night in all species, including humans, and it is pulsatile.1 In humans the peak nocturnal plasma melatonin concentration declines progressively with age, being highest in infants and prepubertal children and lowest in elderly people. Melatonin profoundly influences reproductive function in seasonally breeding mammals. One such species is the Syrian hamster, in which pinealectomy leads to sustained reproductive activity and in which appropriately timed injections of melatonin inhibit reproductive function.2 It is less clear whether melatonin has regulatory actions on the reproductive system in…
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U2 - 10.1056/NEJM199211053271905
DO - 10.1056/NEJM199211053271905
M3 - Article
C2 - 1406837
AN - SCOPUS:0026733570
SN - 0028-4793
VL - 327
SP - 1356
EP - 1359
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 19
ER -