Melatonin: Reducing intracellular hostilities

Russel J Reiter, Dun Xian Tan

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

A large number of diseases/conditions have been found to involve intracellular molecular damage that occurs as a result of hostile, free radical-mediated reactions. Both oxygen and nitrogen-based toxic reactants incessantly mutilate beleaguered, essential molecules, eg, lipids, proteins, DNA, RNA, and so on. The accumulated molecular debris that is a consequence of these reactions could contribute to disease processes and the deteriorative changes of aging. A complex antioxidative defense system has evolved for the purpose of protecting cells from free radicals and the resulting damage. One component of this system is melatonin. This endogenously produced and exogenously acquired (in the diet) indoleamine is a potent direct free radical scavenger and indirect antioxidant (stimulating a variety of antioxidative enzymes). Melatonin has been widely tested to determine its efficacy in protecting against free radical damage in experimental models of heart attack, stroke, Alzheimer disease, Parkinsonism, and others. In these experimental settings, melatonin proved highly effective in reducing molecular damage, cellular death, and tissue loss and, when tested, organismal function was also preserved. In newborn infants with sepsis or respiratory distress syndrome, melatonin was likewise highly effective in limiting the severity of these conditions. Melatonin, which is inexpensive and without significant toxicity, should be considered for more extensive use in humans against free radical-based diseases/conditions.

Original languageEnglish (US)
Pages (from-to)222-228
Number of pages7
JournalEndocrinologist
Volume14
Issue number4
DOIs
StatePublished - Jul 2004

Fingerprint

Hostility
Melatonin
Free Radicals
Free Radical Scavengers
Poisons
Parkinsonian Disorders
Sepsis
Alzheimer Disease
Theoretical Models
Nitrogen
Antioxidants
Stroke
Myocardial Infarction
Newborn Infant
RNA
Oxygen
Diet
Lipids
DNA
Enzymes

Keywords

  • Antioxidant
  • Free radical scavenger
  • Heart attack
  • Melatonin
  • Neurodegenerative diseases
  • Stroke

ASJC Scopus subject areas

  • Endocrinology

Cite this

Melatonin : Reducing intracellular hostilities. / Reiter, Russel J; Tan, Dun Xian.

In: Endocrinologist, Vol. 14, No. 4, 07.2004, p. 222-228.

Research output: Contribution to journalArticle

Reiter, Russel J ; Tan, Dun Xian. / Melatonin : Reducing intracellular hostilities. In: Endocrinologist. 2004 ; Vol. 14, No. 4. pp. 222-228.
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