Melatonin reduces the increase in 8-hydroxy-deoxyguanosine levels in the brain and liver of kainic acid treated rats

Lei Tang, Russel J. Reiter, Zhong Ren Li, Genaro G. Ortiz, Byung Pal Yu, Joaquin J. Garcia

Research output: Contribution to journalArticlepeer-review

53 Scopus citations

Abstract

In the present study, the effect of melatonin on oxidative DNA damage induced by kainic acid (KA) treatment was investigated. 8-hydroxy-deoxyguanosine (8-OH-dG) is a main product of oxidatively damaged DNA and was used as the endpoint in these studies. The levels of 8-OH-dG were found to be elevated in the hippocampus and frontal cortex of rats treated with KA. These elevated levels were significantly reduced in animals that were co-treated with melatonin. Thus, there was no difference in 8-OH-dG levels in the brain of control rats compared to those treated with KA (10 mg/kg) plus melatonin (10 mg/kg). The levels of 8-OH-dG also increased in the liver of rats treated with KA. This rise in oxidatively damaged DNA was also prevented by melatonin administration. Melatonin's ability to reduce KA-induced increases in neural and hepatic 8-OH-dG levels presumably relates to its direct free radical scavenging ability and possibly to other antioxidative actions of melatonin.

Original languageEnglish (US)
Pages (from-to)299-303
Number of pages5
JournalMolecular and Cellular Biochemistry
Volume178
Issue number1-2
DOIs
StatePublished - Mar 31 1998

Keywords

  • 8-hydroxy-deoxyguanosine
  • Free radical
  • Kainic acid
  • Melatonin

ASJC Scopus subject areas

  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

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