Melatonin reduces oxidative/nitrosative stress due to drugs, toxins, metals, and herbicides

Russel J. Reiter; Ahmet Korkmaz; Sergio D. Paredes; Lucien C. Manchester; Dun Xian Tan

Melatonin reduces oxidative/nitrosative stress due to drugs, toxins, metals, and herbicides

Russel J. Reiter, Ahmet Korkmaz, Sergio D. Paredes, Lucien C. Manchester, Dun Xian Tan

Department of Cell Systems & Anatomy

Research output: Contribution to journal › Review article › peer-review

48 Scopus citations

Abstract

The purpose of this brief review is to introduce the reader to the vast amount of published literature related to the free radical scavenging and antioxidative activity of melatonin. However, this review summarizes only a few of the many conditions in which melatonin has been found to be protective against oxidative/nitrosative damage. Melatonin ameliorates the extensive free radical-mediated damage that ensues following exposure to a wide variety of environmental insults. Concisely reviewed in this report are the protective effects of melatonin against toxic prescription drugs, neural toxins, herbicides and metals. The findings have clear implications for the utility of melatonin in toxicology.

Original language	English (US)
Pages (from-to)	609-613
Number of pages	5
Journal	Neuroendocrinology Letters
Volume	29
Issue number	5
State	Published - Oct 2008

Keywords

Antioxidant
Herbicides
Melatonin
Metals
Neural toxins
Nitrosative stress
Oxidative stress
Prescription drugs

ASJC Scopus subject areas

Endocrine and Autonomic Systems
Clinical Neurology
Neurology
Psychiatry and Mental health
Physiology (medical)
Endocrinology, Diabetes and Metabolism
Medicine (miscellaneous)

Cite this

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AU - Tan, Dun Xian

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AB - The purpose of this brief review is to introduce the reader to the vast amount of published literature related to the free radical scavenging and antioxidative activity of melatonin. However, this review summarizes only a few of the many conditions in which melatonin has been found to be protective against oxidative/nitrosative damage. Melatonin ameliorates the extensive free radical-mediated damage that ensues following exposure to a wide variety of environmental insults. Concisely reviewed in this report are the protective effects of melatonin against toxic prescription drugs, neural toxins, herbicides and metals. The findings have clear implications for the utility of melatonin in toxicology.

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KW - Metals

KW - Neural toxins

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KW - Oxidative stress

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Melatonin reduces oxidative/nitrosative stress due to drugs, toxins, metals, and herbicides

Abstract

Keywords

ASJC Scopus subject areas

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