Abstract
Melatonin protection against in vitro kainic acid-induced oxidative damage in homogenates from different rat brain regions is shown. Brain-disrupted cell homogenates from cerebral cortex, cerebellum, hippocampus, hypothalamus, and corpus striatum were incubated with kainate (11.7 mM) with or without different concentrations of melatonin (0.1-4. mM). The concentration of malonaldehyde and 4-hydroxyalkenals was measured as an index of lipid peroxidation. Wistar and Sprague-Dawley rats were used. When administered with kainate, melatonin markedly reduced lipid peroxidation in every brain region of both rat strains. The reduction in lipid peroxidation by melatonin was concentration-dependent and varied from 10% to 100%. The protection conferred by melatonin is likely due, at least in part, to its newly discovered, free radical scavenging ability.
Original language | English (US) |
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Pages (from-to) | 1205-1210 |
Number of pages | 6 |
Journal | FASEB Journal |
Volume | 9 |
Issue number | 12 |
DOIs | |
State | Published - 1995 |
Keywords
- excitatory neurotransmitter
- free radicals
- malonaldehyde
- neuroprotection
- oxidative stress
ASJC Scopus subject areas
- Genetics
- Molecular Biology
- Biochemistry
- Biotechnology