Abstract
Melatonin protection against in vitro kainic acid-induced oxidative damage in homogenates from different rat brain regions is shown. Brain-disrupted cell homogenates from cerebral cortex, cerebellum, hippocampus, hypothalamus, and corpus striatum were incubated with kainate (11.7 mM) with or without different concentrations of melatonin (0.1-4. mM). The concentration of malonaldehyde and 4-hydroxyalkenals was measured as an index of lipid peroxidation. Wistar and Sprague-Dawley rats were used. When administered with kainate, melatonin markedly reduced lipid peroxidation in every brain region of both rat strains. The reduction in lipid peroxidation by melatonin was concentration-dependent and varied from 10% to 100%. The protection conferred by melatonin is likely due, at least in part, to its newly discovered, free radical scavenging ability.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1205-1210 |
| Number of pages | 6 |
| Journal | FASEB Journal |
| Volume | 9 |
| Issue number | 12 |
| State | Published - 1995 |
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Keywords
- excitatory neurotransmitter
- free radicals
- malonaldehyde
- neuroprotection
- oxidative stress
ASJC Scopus subject areas
- Agricultural and Biological Sciences (miscellaneous)
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
- Cell Biology
Cite this
Melatonin reduces kainate-induced lipid peroxidation in homogenates of different brain regions. / Melchiorri, D.; Reiter, Russel J; Sewerynek, E.; Li Dun Chen, Dun Chen; Nistico, G.
In: FASEB Journal, Vol. 9, No. 12, 1995, p. 1205-1210.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Melatonin reduces kainate-induced lipid peroxidation in homogenates of different brain regions
AU - Melchiorri, D.
AU - Reiter, Russel J
AU - Sewerynek, E.
AU - Li Dun Chen, Dun Chen
AU - Nistico, G.
PY - 1995
Y1 - 1995
N2 - Melatonin protection against in vitro kainic acid-induced oxidative damage in homogenates from different rat brain regions is shown. Brain-disrupted cell homogenates from cerebral cortex, cerebellum, hippocampus, hypothalamus, and corpus striatum were incubated with kainate (11.7 mM) with or without different concentrations of melatonin (0.1-4. mM). The concentration of malonaldehyde and 4-hydroxyalkenals was measured as an index of lipid peroxidation. Wistar and Sprague-Dawley rats were used. When administered with kainate, melatonin markedly reduced lipid peroxidation in every brain region of both rat strains. The reduction in lipid peroxidation by melatonin was concentration-dependent and varied from 10% to 100%. The protection conferred by melatonin is likely due, at least in part, to its newly discovered, free radical scavenging ability.
AB - Melatonin protection against in vitro kainic acid-induced oxidative damage in homogenates from different rat brain regions is shown. Brain-disrupted cell homogenates from cerebral cortex, cerebellum, hippocampus, hypothalamus, and corpus striatum were incubated with kainate (11.7 mM) with or without different concentrations of melatonin (0.1-4. mM). The concentration of malonaldehyde and 4-hydroxyalkenals was measured as an index of lipid peroxidation. Wistar and Sprague-Dawley rats were used. When administered with kainate, melatonin markedly reduced lipid peroxidation in every brain region of both rat strains. The reduction in lipid peroxidation by melatonin was concentration-dependent and varied from 10% to 100%. The protection conferred by melatonin is likely due, at least in part, to its newly discovered, free radical scavenging ability.
KW - excitatory neurotransmitter
KW - free radicals
KW - malonaldehyde
KW - neuroprotection
KW - oxidative stress
UR - http://www.scopus.com/inward/record.url?scp=0029082155&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029082155&partnerID=8YFLogxK
M3 - Article
C2 - 7672513
AN - SCOPUS:0029082155
VL - 9
SP - 1205
EP - 1210
JO - FASEB Journal
JF - FASEB Journal
SN - 0892-6638
IS - 12
ER -