Melatonin reduces kainate-induced lipid peroxidation in homogenates of different brain regions

D. Melchiorri, Russel J Reiter, E. Sewerynek, Dun Chen Li Dun Chen, G. Nistico

Research output: Contribution to journalArticle

163 Citations (Scopus)

Abstract

Melatonin protection against in vitro kainic acid-induced oxidative damage in homogenates from different rat brain regions is shown. Brain-disrupted cell homogenates from cerebral cortex, cerebellum, hippocampus, hypothalamus, and corpus striatum were incubated with kainate (11.7 mM) with or without different concentrations of melatonin (0.1-4. mM). The concentration of malonaldehyde and 4-hydroxyalkenals was measured as an index of lipid peroxidation. Wistar and Sprague-Dawley rats were used. When administered with kainate, melatonin markedly reduced lipid peroxidation in every brain region of both rat strains. The reduction in lipid peroxidation by melatonin was concentration-dependent and varied from 10% to 100%. The protection conferred by melatonin is likely due, at least in part, to its newly discovered, free radical scavenging ability.

Original languageEnglish (US)
Pages (from-to)1205-1210
Number of pages6
JournalFASEB Journal
Volume9
Issue number12
StatePublished - 1995

Fingerprint

Kainic Acid
melatonin
Melatonin
Lipid Peroxidation
Brain
lipid peroxidation
brain
Lipids
Rats
rats
Corpus Striatum
cerebral cortex
Scavenging
cerebellum
hippocampus
hypothalamus
Malondialdehyde
Cerebral Cortex
Cerebellum
malondialdehyde

Keywords

  • excitatory neurotransmitter
  • free radicals
  • malonaldehyde
  • neuroprotection
  • oxidative stress

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Melchiorri, D., Reiter, R. J., Sewerynek, E., Li Dun Chen, D. C., & Nistico, G. (1995). Melatonin reduces kainate-induced lipid peroxidation in homogenates of different brain regions. FASEB Journal, 9(12), 1205-1210.

Melatonin reduces kainate-induced lipid peroxidation in homogenates of different brain regions. / Melchiorri, D.; Reiter, Russel J; Sewerynek, E.; Li Dun Chen, Dun Chen; Nistico, G.

In: FASEB Journal, Vol. 9, No. 12, 1995, p. 1205-1210.

Research output: Contribution to journalArticle

Melchiorri, D, Reiter, RJ, Sewerynek, E, Li Dun Chen, DC & Nistico, G 1995, 'Melatonin reduces kainate-induced lipid peroxidation in homogenates of different brain regions', FASEB Journal, vol. 9, no. 12, pp. 1205-1210.
Melchiorri D, Reiter RJ, Sewerynek E, Li Dun Chen DC, Nistico G. Melatonin reduces kainate-induced lipid peroxidation in homogenates of different brain regions. FASEB Journal. 1995;9(12):1205-1210.
Melchiorri, D. ; Reiter, Russel J ; Sewerynek, E. ; Li Dun Chen, Dun Chen ; Nistico, G. / Melatonin reduces kainate-induced lipid peroxidation in homogenates of different brain regions. In: FASEB Journal. 1995 ; Vol. 9, No. 12. pp. 1205-1210.
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