Melatonin: Protection against age-related cardiac pathology

Gaia Favero, Lorenzo Franceschetti, Barbara Buffoli, Mohammed H. Moghadasian, Russel J. Reiter, Luigi F. Rodella, Rita Rezzani

Research output: Contribution to journalReview articlepeer-review

31 Scopus citations


Aging is a complex and progressive process that involves physiological and metabolic deterioration in every organ and system. Cardiovascular diseases are one of the most common causes of mortality and morbidity among elderly subjects worldwide. Most age-related cardiovascular disorders can be influenced by modifiable behaviours such as a healthy diet rich in fruit and vegetables, avoidance of smoking, increased physical activity and reduced stress. The role of diet in prevention of various disorders is a well-established factor, which has an even more important role in the geriatric population. Melatonin, an indoleamine with multiple actions including antioxidant properties, has been identified in a very large number of plant species, including edible plant products and medical herbs. Among products where melatonin has been identified include wine, olive oil, tomato, beer, and others. Interestingly, consumed melatonin in plant foods or melatonin supplementation may promote health benefits by virtue of its multiple properties and it may counteract pathological conditions also related to cardiovascular disorders, carcinogenesis, neurological diseases and aging. In the present review, we summarized melatonin effects against age-related cardiac alterations and abnormalities with a special focus on heart ischemia/reperfusion (IR) injury and myocardial infarction.

Original languageEnglish (US)
Pages (from-to)336-349
Number of pages14
JournalAgeing Research Reviews
StatePublished - May 1 2017


  • Aging
  • Cardiac pathology
  • Heart ischemia/reperfusion injury
  • Melatonin
  • Myocardial infarction

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Aging
  • Molecular Biology
  • Neurology


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