Melatonin plus exercise-based neurorehabilitative therapy for spinal cord injury

Yonggeun Hong, K. J. Palaksha, Kanghui Park, Sookyoung Park, Hyun Dong Kim, Russel J Reiter, Kyu Tae Chang

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Spinal cord injury (SCI) is damage to the spinal cord caused by the trauma or disease that results in compromised or loss of body function. Subsequent to SCI in humans, many individuals have residual motor and sensory deficits that impair functional performance and quality of life. The available treatments for SCI are rehabilitation therapy, activity-based therapies, and pharmacological treatment using antioxidants and their agonists. Among pharmacological treatments, the most efficient and commonly used antioxidant for experimental SCI treatment is melatonin, an indolamine secreted by pineal gland at night. Melatonin's receptor-independent free radical scavenging action and its broad-spectrum antioxidant activity makes it an ideal antioxidant to protect tissue from oxidative stress-induced secondary damage after SCI. Owing to the limitations of an activity-based therapy and antioxidant treatment singly on the functional recovery and oxidative stress-induced secondary damages after SCI, a melatonin plus exercise treatment may be a more effective therapy for SCI. As suggested herein, supplementation with melatonin in conjunction with exercise not only would improve the functional recovery by enhancing the beneficial effects of exercise but would reduce the secondary tissue damage simultaneously. Finally, melatonin may protect against exercise-induced fatigue and impairments. In this review, based on the documented evidence regarding the beneficial effects of melatonin, activity-based therapy and the combination of both on functional recovery, as well as reduction of secondary damage caused by oxidative stress after SCI, we suggest the melatonin combined with exercise would be a novel neurorehabilitative strategy for the faster recovery after SCI.

Original languageEnglish (US)
Pages (from-to)201-209
Number of pages9
JournalJournal of Pineal Research
Volume49
Issue number3
DOIs
StatePublished - Oct 2010

Fingerprint

Melatonin
Spinal Cord Injuries
Antioxidants
Therapeutics
Oxidative Stress
Pharmacology
Melatonin Receptors
Pineal Gland
Spinal Cord Diseases
Free Radicals
Fatigue
Rehabilitation
Quality of Life

Keywords

  • animal model
  • exercise
  • melatonin
  • rehabilitation
  • secondary/oxidative damage
  • spinal cord injury

ASJC Scopus subject areas

  • Endocrinology

Cite this

Melatonin plus exercise-based neurorehabilitative therapy for spinal cord injury. / Hong, Yonggeun; Palaksha, K. J.; Park, Kanghui; Park, Sookyoung; Kim, Hyun Dong; Reiter, Russel J; Chang, Kyu Tae.

In: Journal of Pineal Research, Vol. 49, No. 3, 10.2010, p. 201-209.

Research output: Contribution to journalArticle

Hong, Yonggeun ; Palaksha, K. J. ; Park, Kanghui ; Park, Sookyoung ; Kim, Hyun Dong ; Reiter, Russel J ; Chang, Kyu Tae. / Melatonin plus exercise-based neurorehabilitative therapy for spinal cord injury. In: Journal of Pineal Research. 2010 ; Vol. 49, No. 3. pp. 201-209.
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