Melatonin: Lowering the high price of free radicals

Research output: Contribution to journalArticlepeer-review

300 Scopus citations


The endogenous antioxidative defense system reduces molecular toxicity of oxygen and nitrogen-based reactive species. Melatonin is an efficient direct and indirect antioxidant. It detoxifies the highly reactive hydroxyl radical and neutralizes other toxic species, including singlet oxygen, hydrogen peroxide, nitric oxide, and peroxynitrite anion, and stimulates several antioxidative enzymes.

Original languageEnglish (US)
Pages (from-to)246-250
Number of pages5
JournalNews in Physiological Sciences
Issue number5
StatePublished - Oct 2000

ASJC Scopus subject areas

  • Physiology


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