Melatonin inhibits luteinizing hormone releasing hormone (LHRH) induction of LH release from fetal rat pituitary cells

Atsuhiko Hattori; Damon C. Herbert; Mary K. Vaughan; Ken Yaga; Russel J. Reiter

doi:10.1016/0304-3940(94)11181-H

Melatonin inhibits luteinizing hormone releasing hormone (LHRH) induction of LH release from fetal rat pituitary cells

Atsuhiko Hattori, Damon C. Herbert, Mary K. Vaughan, Ken Yaga, Russel J. Reiter

Department of Cell Systems & Anatomy

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

The in vitro effect of melatonin on the release of luteinizing hormone (LH) and follicle stimulating hormone (FSH) from fetal rat pituitary cells was investigated. A significant inhibition of LH release induced by 10^-9 M luteinizing hormone releasing hormone (LHRH) was seen when cells were incubated with 10^-9 M melatonin. FSH release was unaffected by either LHRH alone or LHRH in combination with melatonin. In addition, the significant inhibitory effect of melatonin was reduced by pretreatment of the pituitary cells with 10^-10 M melatonin. These findings indicate that melatonin can act directly on the fetal pituitary gland to suppress LHRH-induced release of LH perhaps by a mechanism which eventually involves down-regulation of the melatonin receptors.

Original language	English (US)
Pages (from-to)	109-112
Number of pages	4
Journal	Neuroscience Letters
Volume	184
Issue number	2
DOIs	https://doi.org/10.1016/0304-3940(94)11181-H
State	Published - Jan 23 1995

Keywords

Fetus
Follicle stimulating hormone
Luteinizing hormone
Luteinizing hormone releasing hormone
Melatonin
Rat

ASJC Scopus subject areas

General Neuroscience

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10.1016/0304-3940(94)11181-H

Cite this

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title = "Melatonin inhibits luteinizing hormone releasing hormone (LHRH) induction of LH release from fetal rat pituitary cells",

abstract = "The in vitro effect of melatonin on the release of luteinizing hormone (LH) and follicle stimulating hormone (FSH) from fetal rat pituitary cells was investigated. A significant inhibition of LH release induced by 10-9 M luteinizing hormone releasing hormone (LHRH) was seen when cells were incubated with 10-9 M melatonin. FSH release was unaffected by either LHRH alone or LHRH in combination with melatonin. In addition, the significant inhibitory effect of melatonin was reduced by pretreatment of the pituitary cells with 10-10 M melatonin. These findings indicate that melatonin can act directly on the fetal pituitary gland to suppress LHRH-induced release of LH perhaps by a mechanism which eventually involves down-regulation of the melatonin receptors.",

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T1 - Melatonin inhibits luteinizing hormone releasing hormone (LHRH) induction of LH release from fetal rat pituitary cells

AU - Hattori, Atsuhiko

AU - Herbert, Damon C.

AU - Vaughan, Mary K.

AU - Yaga, Ken

AU - Reiter, Russel J.

PY - 1995/1/23

Y1 - 1995/1/23

N2 - The in vitro effect of melatonin on the release of luteinizing hormone (LH) and follicle stimulating hormone (FSH) from fetal rat pituitary cells was investigated. A significant inhibition of LH release induced by 10-9 M luteinizing hormone releasing hormone (LHRH) was seen when cells were incubated with 10-9 M melatonin. FSH release was unaffected by either LHRH alone or LHRH in combination with melatonin. In addition, the significant inhibitory effect of melatonin was reduced by pretreatment of the pituitary cells with 10-10 M melatonin. These findings indicate that melatonin can act directly on the fetal pituitary gland to suppress LHRH-induced release of LH perhaps by a mechanism which eventually involves down-regulation of the melatonin receptors.

AB - The in vitro effect of melatonin on the release of luteinizing hormone (LH) and follicle stimulating hormone (FSH) from fetal rat pituitary cells was investigated. A significant inhibition of LH release induced by 10-9 M luteinizing hormone releasing hormone (LHRH) was seen when cells were incubated with 10-9 M melatonin. FSH release was unaffected by either LHRH alone or LHRH in combination with melatonin. In addition, the significant inhibitory effect of melatonin was reduced by pretreatment of the pituitary cells with 10-10 M melatonin. These findings indicate that melatonin can act directly on the fetal pituitary gland to suppress LHRH-induced release of LH perhaps by a mechanism which eventually involves down-regulation of the melatonin receptors.

KW - Fetus

KW - Follicle stimulating hormone

KW - Luteinizing hormone

KW - Luteinizing hormone releasing hormone

KW - Melatonin

KW - Rat

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Melatonin inhibits luteinizing hormone releasing hormone (LHRH) induction of LH release from fetal rat pituitary cells

Abstract

Keywords

ASJC Scopus subject areas

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