Melatonin inhibition of pineal antigonadotrophic activity in male rats

A. F. Banks, R. J. Reiter

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

The influence of subcutaneous implants of melatonin on reproductive organ growth in neonatally testosterone propionate-(TP)-treatcd, blinded rats was investigated. The testes and accessory sex organs of rats that were TP-treated and blinded grew significantly slower than those of intact control rats. Either treatment of animals with melatonin or pinealectomy partially restored growth of the reproductive organs. In that the effects of melatonin treatment were similar to those of pinealectomy in this experiment model, it is speculated that melatonin may not be the principal pineal antigonadotrophic substance in the male rat.

Original languageEnglish (US)
Pages (from-to)351-356
Number of pages6
JournalHormone Research in Paediatrics
Volume6
Issue number5-6
DOIs
StatePublished - 1975

Keywords

  • Melatonin-Pineal gland Antigonadotrophic activity
  • Pinealectomy Male rat
  • Reproductive organs Neonatal androgen treatment

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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