Melatonin in the oral cavity: Physiological and pathological implications

Russel J Reiter, S. A. Rosales-Corral, X. Y. Liu, D. Acuna-Castroviejo, G. Escames, D. X. Tan

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Background and Objectives: The purpose of this article was to summarize what is known about the function of melatonin in the oral cavity. Material and Methods: Databases were searched for the relevant published literature to 30 November, 2013. The following search items were used in various combinations: melatonin, gingiva, periodontium, inflammation, herpes, alveolar bone, periodontal ligament, dental implants, xerostomia, methacrylate, chlorhexidine, cancer. The literature uncovered is summarized herein. Results: Salivary melatonin levels exhibit a circadian rhythm with highest values at night. Melatonin has both receptor-mediated and receptor-independent actions in cells of the oral cavity. Melatonin is released into the saliva by the acinar cells of the major salivary glands and via the gingival fluid. Functions of melatonin in the oral cavity are likely to relate primarily to its anti-inflammatory and antioxidant activities. These actions may suppress inflammation of the gingiva and periodontium, reduce alveolar bone loss, abrogate herpes lesions, enhance osteointegration of dental implants, limit oral cancer, and suppress disorders that have a free radical component. Sublingual melatonin tablets or oral melatonin sprays and topical melatonin-containing gel, if used on a regular basis, may improve overall oral health and reduce mucosal lesions. Conclusion: Collectively, the results indicate that endogenously-produced and exogenously-applied melatonin are beneficial to the oral cavity.

Original languageEnglish (US)
Pages (from-to)9-17
Number of pages9
JournalJournal of Periodontal Research
Volume50
Issue number1
DOIs
StatePublished - Feb 1 2015

Fingerprint

Melatonin
Mouth
Periodontium
Dental Implants
Gingiva
Oral Sprays
Alveolar Bone Loss
Inflammation
Xerostomia
Periodontal Ligament
Chlorhexidine
Methacrylates
Acinar Cells
Mouth Neoplasms
Oral Health
Circadian Rhythm
Salivary Glands
Saliva
Tablets
Free Radicals

Keywords

  • Anti-inflammatory
  • Antioxidant
  • Osteointegration
  • Periodontitis
  • Saliva
  • Tooth loss

ASJC Scopus subject areas

  • Periodontics

Cite this

Reiter, R. J., Rosales-Corral, S. A., Liu, X. Y., Acuna-Castroviejo, D., Escames, G., & Tan, D. X. (2015). Melatonin in the oral cavity: Physiological and pathological implications. Journal of Periodontal Research, 50(1), 9-17. https://doi.org/10.1111/jre.12176

Melatonin in the oral cavity : Physiological and pathological implications. / Reiter, Russel J; Rosales-Corral, S. A.; Liu, X. Y.; Acuna-Castroviejo, D.; Escames, G.; Tan, D. X.

In: Journal of Periodontal Research, Vol. 50, No. 1, 01.02.2015, p. 9-17.

Research output: Contribution to journalArticle

Reiter, RJ, Rosales-Corral, SA, Liu, XY, Acuna-Castroviejo, D, Escames, G & Tan, DX 2015, 'Melatonin in the oral cavity: Physiological and pathological implications', Journal of Periodontal Research, vol. 50, no. 1, pp. 9-17. https://doi.org/10.1111/jre.12176
Reiter, Russel J ; Rosales-Corral, S. A. ; Liu, X. Y. ; Acuna-Castroviejo, D. ; Escames, G. ; Tan, D. X. / Melatonin in the oral cavity : Physiological and pathological implications. In: Journal of Periodontal Research. 2015 ; Vol. 50, No. 1. pp. 9-17.
@article{37f406e8997b4951ae301f824f5d0e71,
title = "Melatonin in the oral cavity: Physiological and pathological implications",
abstract = "Background and Objectives: The purpose of this article was to summarize what is known about the function of melatonin in the oral cavity. Material and Methods: Databases were searched for the relevant published literature to 30 November, 2013. The following search items were used in various combinations: melatonin, gingiva, periodontium, inflammation, herpes, alveolar bone, periodontal ligament, dental implants, xerostomia, methacrylate, chlorhexidine, cancer. The literature uncovered is summarized herein. Results: Salivary melatonin levels exhibit a circadian rhythm with highest values at night. Melatonin has both receptor-mediated and receptor-independent actions in cells of the oral cavity. Melatonin is released into the saliva by the acinar cells of the major salivary glands and via the gingival fluid. Functions of melatonin in the oral cavity are likely to relate primarily to its anti-inflammatory and antioxidant activities. These actions may suppress inflammation of the gingiva and periodontium, reduce alveolar bone loss, abrogate herpes lesions, enhance osteointegration of dental implants, limit oral cancer, and suppress disorders that have a free radical component. Sublingual melatonin tablets or oral melatonin sprays and topical melatonin-containing gel, if used on a regular basis, may improve overall oral health and reduce mucosal lesions. Conclusion: Collectively, the results indicate that endogenously-produced and exogenously-applied melatonin are beneficial to the oral cavity.",
keywords = "Anti-inflammatory, Antioxidant, Osteointegration, Periodontitis, Saliva, Tooth loss",
author = "Reiter, {Russel J} and Rosales-Corral, {S. A.} and Liu, {X. Y.} and D. Acuna-Castroviejo and G. Escames and Tan, {D. X.}",
year = "2015",
month = "2",
day = "1",
doi = "10.1111/jre.12176",
language = "English (US)",
volume = "50",
pages = "9--17",
journal = "Journal of Periodontal Research",
issn = "0022-3484",
publisher = "Blackwell Munksgaard",
number = "1",

}

TY - JOUR

T1 - Melatonin in the oral cavity

T2 - Physiological and pathological implications

AU - Reiter, Russel J

AU - Rosales-Corral, S. A.

AU - Liu, X. Y.

AU - Acuna-Castroviejo, D.

AU - Escames, G.

AU - Tan, D. X.

PY - 2015/2/1

Y1 - 2015/2/1

N2 - Background and Objectives: The purpose of this article was to summarize what is known about the function of melatonin in the oral cavity. Material and Methods: Databases were searched for the relevant published literature to 30 November, 2013. The following search items were used in various combinations: melatonin, gingiva, periodontium, inflammation, herpes, alveolar bone, periodontal ligament, dental implants, xerostomia, methacrylate, chlorhexidine, cancer. The literature uncovered is summarized herein. Results: Salivary melatonin levels exhibit a circadian rhythm with highest values at night. Melatonin has both receptor-mediated and receptor-independent actions in cells of the oral cavity. Melatonin is released into the saliva by the acinar cells of the major salivary glands and via the gingival fluid. Functions of melatonin in the oral cavity are likely to relate primarily to its anti-inflammatory and antioxidant activities. These actions may suppress inflammation of the gingiva and periodontium, reduce alveolar bone loss, abrogate herpes lesions, enhance osteointegration of dental implants, limit oral cancer, and suppress disorders that have a free radical component. Sublingual melatonin tablets or oral melatonin sprays and topical melatonin-containing gel, if used on a regular basis, may improve overall oral health and reduce mucosal lesions. Conclusion: Collectively, the results indicate that endogenously-produced and exogenously-applied melatonin are beneficial to the oral cavity.

AB - Background and Objectives: The purpose of this article was to summarize what is known about the function of melatonin in the oral cavity. Material and Methods: Databases were searched for the relevant published literature to 30 November, 2013. The following search items were used in various combinations: melatonin, gingiva, periodontium, inflammation, herpes, alveolar bone, periodontal ligament, dental implants, xerostomia, methacrylate, chlorhexidine, cancer. The literature uncovered is summarized herein. Results: Salivary melatonin levels exhibit a circadian rhythm with highest values at night. Melatonin has both receptor-mediated and receptor-independent actions in cells of the oral cavity. Melatonin is released into the saliva by the acinar cells of the major salivary glands and via the gingival fluid. Functions of melatonin in the oral cavity are likely to relate primarily to its anti-inflammatory and antioxidant activities. These actions may suppress inflammation of the gingiva and periodontium, reduce alveolar bone loss, abrogate herpes lesions, enhance osteointegration of dental implants, limit oral cancer, and suppress disorders that have a free radical component. Sublingual melatonin tablets or oral melatonin sprays and topical melatonin-containing gel, if used on a regular basis, may improve overall oral health and reduce mucosal lesions. Conclusion: Collectively, the results indicate that endogenously-produced and exogenously-applied melatonin are beneficial to the oral cavity.

KW - Anti-inflammatory

KW - Antioxidant

KW - Osteointegration

KW - Periodontitis

KW - Saliva

KW - Tooth loss

UR - http://www.scopus.com/inward/record.url?scp=84920834811&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84920834811&partnerID=8YFLogxK

U2 - 10.1111/jre.12176

DO - 10.1111/jre.12176

M3 - Article

C2 - 24665831

AN - SCOPUS:84920834811

VL - 50

SP - 9

EP - 17

JO - Journal of Periodontal Research

JF - Journal of Periodontal Research

SN - 0022-3484

IS - 1

ER -