Abstract
In cancer cells, glucose is primarily metabolized to pyruvate and then to lactate in the cytosol. By allowing the conversion of pyruvate to acetyl-CoA in mitochondria, melatonin reprograms glucose metabolism in cancer cells to a normal cell phenotype. Acetyl-CoA in the mitochondria also serves as a necessary co-factor for the rate-limiting enzyme in melatonin synthesis, thus ensuring melatonin production in mitochondria of normal cells.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 86-95 |
| Number of pages | 10 |
| Journal | Physiology |
| Volume | 35 |
| Issue number | 2 |
| DOIs | |
| State | Published - 2020 |
Keywords
- Free radicals
- Lactate metabolism
- Oxidative phosphorylation
- Oxidative stress
- Pyruvate dehydrogenase complex
- Pyruvate dehydrogenase kinase
- Reactive oxygen species
- Warburg effect
ASJC Scopus subject areas
- Physiology