Melatonin in mitochondria: Mitigating clear and present dangers

Russel J. Reiter; Qiang Ma; Ramaswamy Sharma

doi:10.1152/physiol.00034.2019

Melatonin in mitochondria: Mitigating clear and present dangers

Russel J. Reiter, Qiang Ma, Ramaswamy Sharma

Department of Cell Systems & Anatomy

Research output: Contribution to journal › Review article › peer-review

92 Scopus citations

Abstract

In cancer cells, glucose is primarily metabolized to pyruvate and then to lactate in the cytosol. By allowing the conversion of pyruvate to acetyl-CoA in mitochondria, melatonin reprograms glucose metabolism in cancer cells to a normal cell phenotype. Acetyl-CoA in the mitochondria also serves as a necessary co-factor for the rate-limiting enzyme in melatonin synthesis, thus ensuring melatonin production in mitochondria of normal cells.

Original language	English (US)
Pages (from-to)	86-95
Number of pages	10
Journal	Physiology
Volume	35
Issue number	2
DOIs	https://doi.org/10.1152/physiol.00034.2019
State	Published - 2020

Keywords

Free radicals
Lactate metabolism
Oxidative phosphorylation
Oxidative stress
Pyruvate dehydrogenase complex
Pyruvate dehydrogenase kinase
Reactive oxygen species
Warburg effect

ASJC Scopus subject areas

Physiology

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10.1152/physiol.00034.2019

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title = "Melatonin in mitochondria: Mitigating clear and present dangers",

abstract = "In cancer cells, glucose is primarily metabolized to pyruvate and then to lactate in the cytosol. By allowing the conversion of pyruvate to acetyl-CoA in mitochondria, melatonin reprograms glucose metabolism in cancer cells to a normal cell phenotype. Acetyl-CoA in the mitochondria also serves as a necessary co-factor for the rate-limiting enzyme in melatonin synthesis, thus ensuring melatonin production in mitochondria of normal cells.",

keywords = "Free radicals, Lactate metabolism, Oxidative phosphorylation, Oxidative stress, Pyruvate dehydrogenase complex, Pyruvate dehydrogenase kinase, Reactive oxygen species, Warburg effect",

author = "Reiter, {Russel J.} and Qiang Ma and Ramaswamy Sharma",

note = "Publisher Copyright: {\textcopyright} 2020 Int. Union Physiol. Sci./Am. Physiol. Soc.",

year = "2020",

doi = "10.1152/physiol.00034.2019",

language = "English (US)",

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TY - JOUR

T1 - Melatonin in mitochondria

T2 - Mitigating clear and present dangers

AU - Reiter, Russel J.

AU - Ma, Qiang

AU - Sharma, Ramaswamy

PY - 2020

Y1 - 2020

N2 - In cancer cells, glucose is primarily metabolized to pyruvate and then to lactate in the cytosol. By allowing the conversion of pyruvate to acetyl-CoA in mitochondria, melatonin reprograms glucose metabolism in cancer cells to a normal cell phenotype. Acetyl-CoA in the mitochondria also serves as a necessary co-factor for the rate-limiting enzyme in melatonin synthesis, thus ensuring melatonin production in mitochondria of normal cells.

AB - In cancer cells, glucose is primarily metabolized to pyruvate and then to lactate in the cytosol. By allowing the conversion of pyruvate to acetyl-CoA in mitochondria, melatonin reprograms glucose metabolism in cancer cells to a normal cell phenotype. Acetyl-CoA in the mitochondria also serves as a necessary co-factor for the rate-limiting enzyme in melatonin synthesis, thus ensuring melatonin production in mitochondria of normal cells.

KW - Free radicals

KW - Lactate metabolism

KW - Oxidative phosphorylation

KW - Oxidative stress

KW - Pyruvate dehydrogenase complex

KW - Pyruvate dehydrogenase kinase

KW - Reactive oxygen species

KW - Warburg effect

UR - http://www.scopus.com/inward/record.url?scp=85079037451&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85079037451&partnerID=8YFLogxK

U2 - 10.1152/physiol.00034.2019

DO - 10.1152/physiol.00034.2019

M3 - Review article

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AN - SCOPUS:85079037451

SN - 1548-9213

VL - 35

SP - 86

EP - 95

JO - Physiology

JF - Physiology

IS - 2

ER -

Melatonin in mitochondria: Mitigating clear and present dangers

Abstract

Keywords

ASJC Scopus subject areas

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